T-cell anergy

Fernando Macian-Juan, Sin Hyeog Im, Francisco J. García-Cózar, Anjana Rao

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for the induction and maintenance of T-cell anergy. These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalCurrent Opinion in Immunology
Volume16
Issue number2
DOIs
StatePublished - Apr 2004

Fingerprint

T-Lymphocytes
Peripheral Tolerance
Thymus Gland
Maintenance
Antigens

Keywords

  • CTLA-4
  • Cytotoxic T lymphocyte antigen 4
  • DC
  • Dendritic cell
  • GM-CSF
  • Granulocyte-macrophage colony-stimulating factor
  • IFN
  • Ig-like transcript
  • IL
  • ILT
  • Interferon
  • Interleukin
  • NFAT
  • Nuclear factor of activated T cells
  • T-cell receptor
  • TCR
  • TGF

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Macian-Juan, F., Im, S. H., García-Cózar, F. J., & Rao, A. (2004). T-cell anergy. Current Opinion in Immunology, 16(2), 209-216. https://doi.org/10.1016/j.coi.2004.01.013

T-cell anergy. / Macian-Juan, Fernando; Im, Sin Hyeog; García-Cózar, Francisco J.; Rao, Anjana.

In: Current Opinion in Immunology, Vol. 16, No. 2, 04.2004, p. 209-216.

Research output: Contribution to journalArticle

Macian-Juan, F, Im, SH, García-Cózar, FJ & Rao, A 2004, 'T-cell anergy', Current Opinion in Immunology, vol. 16, no. 2, pp. 209-216. https://doi.org/10.1016/j.coi.2004.01.013
Macian-Juan, Fernando ; Im, Sin Hyeog ; García-Cózar, Francisco J. ; Rao, Anjana. / T-cell anergy. In: Current Opinion in Immunology. 2004 ; Vol. 16, No. 2. pp. 209-216.
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