T-cell anergy

Fernando Macián; Sin Hyeog Im; Francisco J. García-Cózar; Anjana Rao

doi:10.1016/j.coi.2004.01.013

T-cell anergy

Fernando Macián, Sin Hyeog Im, Francisco J. García-Cózar, Anjana Rao

Pathology

Research output: Contribution to journal › Review article › peer-review

128 Scopus citations

Abstract

Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for the induction and maintenance of T-cell anergy. These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state.

Original language	English (US)
Pages (from-to)	209-216
Number of pages	8
Journal	Current Opinion in Immunology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.coi.2004.01.013
State	Published - Apr 2004

Keywords

CTLA-4
Cytotoxic T lymphocyte antigen 4
DC
Dendritic cell
GM-CSF
Granulocyte-macrophage colony-stimulating factor
IFN
IL
ILT
Ig-like transcript
Interferon
Interleukin
NFAT
Nuclear factor of activated T cells
T-cell receptor
TCR
TGF

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.coi.2004.01.013

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title = "T-cell anergy",

abstract = "Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for the induction and maintenance of T-cell anergy. These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state.",

keywords = "CTLA-4, Cytotoxic T lymphocyte antigen 4, DC, Dendritic cell, GM-CSF, Granulocyte-macrophage colony-stimulating factor, IFN, IL, ILT, Ig-like transcript, Interferon, Interleukin, NFAT, Nuclear factor of activated T cells, T-cell receptor, TCR, TGF",

author = "Fernando Maci{\'a}n and Im, {Sin Hyeog} and Garc{\'i}a-C{\'o}zar, {Francisco J.} and Anjana Rao",

note = "Funding Information: We apologize that, because of space constraints, we were unable to cite many seminal contributions from investigators in the field. Supported by an Irene Diamond Foundation grant (to FM), Spanish Ministry of Science and Technology (MCYT) grants SAF2001-3449 and Ramon y Cajal program, Spanish Ministry of Health (MSC) grant FIS 01/0896 and, Junta de Andalucia (JA) grants CTS498 and SAS165/02 (to FJC), National Institutes of Health grant AI48213 (to AR), and a Cancer Research Institute fellowship (to S-HI). ",

year = "2004",

month = apr,

doi = "10.1016/j.coi.2004.01.013",

language = "English (US)",

volume = "16",

pages = "209--216",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - T-cell anergy

AU - Macián, Fernando

AU - Im, Sin Hyeog

AU - García-Cózar, Francisco J.

AU - Rao, Anjana

N1 - Funding Information: We apologize that, because of space constraints, we were unable to cite many seminal contributions from investigators in the field. Supported by an Irene Diamond Foundation grant (to FM), Spanish Ministry of Science and Technology (MCYT) grants SAF2001-3449 and Ramon y Cajal program, Spanish Ministry of Health (MSC) grant FIS 01/0896 and, Junta de Andalucia (JA) grants CTS498 and SAS165/02 (to FJC), National Institutes of Health grant AI48213 (to AR), and a Cancer Research Institute fellowship (to S-HI).

PY - 2004/4

Y1 - 2004/4

N2 - Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for the induction and maintenance of T-cell anergy. These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state.

AB - Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for the induction and maintenance of T-cell anergy. These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state.

KW - CTLA-4

KW - Cytotoxic T lymphocyte antigen 4

KW - DC

KW - Dendritic cell

KW - GM-CSF

KW - Granulocyte-macrophage colony-stimulating factor

KW - IFN

KW - IL

KW - ILT

KW - Ig-like transcript

KW - Interferon

KW - Interleukin

KW - NFAT

KW - Nuclear factor of activated T cells

KW - T-cell receptor

KW - TCR

KW - TGF

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U2 - 10.1016/j.coi.2004.01.013

DO - 10.1016/j.coi.2004.01.013

M3 - Review article

C2 - 15023415

AN - SCOPUS:1542351324

SN - 0952-7915

VL - 16

SP - 209

EP - 216

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 2

ER -

T-cell anergy

Abstract

Keywords

ASJC Scopus subject areas

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