TY - JOUR
T1 - T cell activation predicts carotid artery stiffness among HIV-infected women
AU - Kaplan, Robert C.
AU - Sinclair, Elizabeth
AU - Landay, Alan L.
AU - Lurain, Nell
AU - Sharrett, A. Richey
AU - Gange, Stephen J.
AU - Xue, Xiaonan
AU - Parrinello, Christina M.
AU - Hunt, Peter
AU - Deeks, Steven G.
AU - Hodis, Howard N.
N1 - Funding Information:
This work was supported by the National Institute of Allergy and Infectious Diseases [grant numbers UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, UO1-AI-42590] and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development [grant number UO1-HD-32632]. This study was co-funded by the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute on Deafness and Other Communication Disorders. Additional co-funding was provided by the National Heart, Lung and Blood Institute (grant numbers 1R01HL095140, 1R01HL083760 to R.C.K.). Funding support was also provided by the National Center for Research Resources (UCSF-CTSI grant number UL1 RR024131), NIH/NIAID funding to the UCSF-GIVI Center for AIDS Research (P30AI027763) and NCR funding to the UCSF Clinical and Translational Science Institute (UL1RR024131). The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
PY - 2011/7
Y1 - 2011/7
N2 - Objectives: HIV disease is associated with increased arterial stiffness, which may be related to inflammation provoked by HIV-related immune perturbation. We assessed the association of T cell markers of immune activation and immunosenescence with carotid artery stiffness among HIV-infected women. Methods: Among 114 HIV-infected and 43 HIV-uninfected women, we measured CD4+ and CD8+ T cell populations expressing activation (CD38+HLA-DR+) and senescence (CD28-CD57+) markers. We then related these measures of immune status with parameters of carotid artery stiffness, including decreased distensibility, and increased Young's elastic modulus, as assessed by B-mode ultrasound. Results: HIV infection was associated with increased CD4+ T cell activation, CD8+ T cell activation and CD8+ T cell senescence. Among HIV-infected women, adjusted for age, HIV medications, and vascular risk factors, higher CD4+CD38+HLA-DR+ T cell frequency was associated with decreased carotid artery distensibility (β= -2.00, 95% confidence interval [CI] = -3.86, -0.14, P= 0.04) and increased Young's modulus (β= 1.00, 95% CI = 0.03, 1.97, P= 0.04). These associations were affected little by further adjustment for CD4+ T cell count and viral load. Among HIV-infected women, higher frequencies of immunosenescent T cells, including CD4+CD28-CD57+ and CD8+CD28-CD57+ T cells, were also associated with decreased arterial distensibility. Among HIV-uninfected women, frequencies of activated or senescent T cells were not significantly associated with measures of carotid stiffness. Discussion: T cell activation and senescence are associated with arterial stiffness, suggesting that pro-inflammatory populations of T cells may produce functional or structural vascular changes in HIV-infected women.
AB - Objectives: HIV disease is associated with increased arterial stiffness, which may be related to inflammation provoked by HIV-related immune perturbation. We assessed the association of T cell markers of immune activation and immunosenescence with carotid artery stiffness among HIV-infected women. Methods: Among 114 HIV-infected and 43 HIV-uninfected women, we measured CD4+ and CD8+ T cell populations expressing activation (CD38+HLA-DR+) and senescence (CD28-CD57+) markers. We then related these measures of immune status with parameters of carotid artery stiffness, including decreased distensibility, and increased Young's elastic modulus, as assessed by B-mode ultrasound. Results: HIV infection was associated with increased CD4+ T cell activation, CD8+ T cell activation and CD8+ T cell senescence. Among HIV-infected women, adjusted for age, HIV medications, and vascular risk factors, higher CD4+CD38+HLA-DR+ T cell frequency was associated with decreased carotid artery distensibility (β= -2.00, 95% confidence interval [CI] = -3.86, -0.14, P= 0.04) and increased Young's modulus (β= 1.00, 95% CI = 0.03, 1.97, P= 0.04). These associations were affected little by further adjustment for CD4+ T cell count and viral load. Among HIV-infected women, higher frequencies of immunosenescent T cells, including CD4+CD28-CD57+ and CD8+CD28-CD57+ T cells, were also associated with decreased arterial distensibility. Among HIV-uninfected women, frequencies of activated or senescent T cells were not significantly associated with measures of carotid stiffness. Discussion: T cell activation and senescence are associated with arterial stiffness, suggesting that pro-inflammatory populations of T cells may produce functional or structural vascular changes in HIV-infected women.
KW - Cardiovascular disease
KW - HIV
KW - Inflammation
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U2 - 10.1016/j.atherosclerosis.2011.03.011
DO - 10.1016/j.atherosclerosis.2011.03.011
M3 - Article
C2 - 21492857
AN - SCOPUS:79960232165
SN - 0021-9150
VL - 217
SP - 207
EP - 213
JO - Atherosclerosis
JF - Atherosclerosis
IS - 1
ER -