T cell activation predicts carotid artery stiffness among HIV-infected women

Robert C. Kaplan, Elizabeth Sinclair, Alan L. Landay, Nell Lurain, A. Richey Sharrett, Stephen J. Gange, Xiaonan (Nan) Xue, Christina M. Parrinello, Peter Hunt, Steven G. Deeks, Howard N. Hodis

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Abstract

Objectives: HIV disease is associated with increased arterial stiffness, which may be related to inflammation provoked by HIV-related immune perturbation. We assessed the association of T cell markers of immune activation and immunosenescence with carotid artery stiffness among HIV-infected women. Methods: Among 114 HIV-infected and 43 HIV-uninfected women, we measured CD4+ and CD8+ T cell populations expressing activation (CD38+HLA-DR+) and senescence (CD28-CD57+) markers. We then related these measures of immune status with parameters of carotid artery stiffness, including decreased distensibility, and increased Young's elastic modulus, as assessed by B-mode ultrasound. Results: HIV infection was associated with increased CD4+ T cell activation, CD8+ T cell activation and CD8+ T cell senescence. Among HIV-infected women, adjusted for age, HIV medications, and vascular risk factors, higher CD4+CD38+HLA-DR+ T cell frequency was associated with decreased carotid artery distensibility (β= -2.00, 95% confidence interval [CI] = -3.86, -0.14, P= 0.04) and increased Young's modulus (β= 1.00, 95% CI = 0.03, 1.97, P= 0.04). These associations were affected little by further adjustment for CD4+ T cell count and viral load. Among HIV-infected women, higher frequencies of immunosenescent T cells, including CD4+CD28-CD57+ and CD8+CD28-CD57+ T cells, were also associated with decreased arterial distensibility. Among HIV-uninfected women, frequencies of activated or senescent T cells were not significantly associated with measures of carotid stiffness. Discussion: T cell activation and senescence are associated with arterial stiffness, suggesting that pro-inflammatory populations of T cells may produce functional or structural vascular changes in HIV-infected women.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalAtherosclerosis
Volume217
Issue number1
DOIs
StatePublished - Jul 2011

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Carotid Arteries
HIV
T-Lymphocytes
Elastic Modulus
Vascular Stiffness
Cell Aging
HLA-DR Antigens
Confidence Intervals
CD4 Lymphocyte Count
Viral Load
Population
HIV Infections
Blood Vessels
Biomarkers
Inflammation

Keywords

  • Cardiovascular disease
  • HIV
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kaplan, R. C., Sinclair, E., Landay, A. L., Lurain, N., Sharrett, A. R., Gange, S. J., ... Hodis, H. N. (2011). T cell activation predicts carotid artery stiffness among HIV-infected women. Atherosclerosis, 217(1), 207-213. https://doi.org/10.1016/j.atherosclerosis.2011.03.011

T cell activation predicts carotid artery stiffness among HIV-infected women. / Kaplan, Robert C.; Sinclair, Elizabeth; Landay, Alan L.; Lurain, Nell; Sharrett, A. Richey; Gange, Stephen J.; Xue, Xiaonan (Nan); Parrinello, Christina M.; Hunt, Peter; Deeks, Steven G.; Hodis, Howard N.

In: Atherosclerosis, Vol. 217, No. 1, 07.2011, p. 207-213.

Research output: Contribution to journalArticle

Kaplan, RC, Sinclair, E, Landay, AL, Lurain, N, Sharrett, AR, Gange, SJ, Xue, XN, Parrinello, CM, Hunt, P, Deeks, SG & Hodis, HN 2011, 'T cell activation predicts carotid artery stiffness among HIV-infected women', Atherosclerosis, vol. 217, no. 1, pp. 207-213. https://doi.org/10.1016/j.atherosclerosis.2011.03.011
Kaplan, Robert C. ; Sinclair, Elizabeth ; Landay, Alan L. ; Lurain, Nell ; Sharrett, A. Richey ; Gange, Stephen J. ; Xue, Xiaonan (Nan) ; Parrinello, Christina M. ; Hunt, Peter ; Deeks, Steven G. ; Hodis, Howard N. / T cell activation predicts carotid artery stiffness among HIV-infected women. In: Atherosclerosis. 2011 ; Vol. 217, No. 1. pp. 207-213.
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abstract = "Objectives: HIV disease is associated with increased arterial stiffness, which may be related to inflammation provoked by HIV-related immune perturbation. We assessed the association of T cell markers of immune activation and immunosenescence with carotid artery stiffness among HIV-infected women. Methods: Among 114 HIV-infected and 43 HIV-uninfected women, we measured CD4+ and CD8+ T cell populations expressing activation (CD38+HLA-DR+) and senescence (CD28-CD57+) markers. We then related these measures of immune status with parameters of carotid artery stiffness, including decreased distensibility, and increased Young's elastic modulus, as assessed by B-mode ultrasound. Results: HIV infection was associated with increased CD4+ T cell activation, CD8+ T cell activation and CD8+ T cell senescence. Among HIV-infected women, adjusted for age, HIV medications, and vascular risk factors, higher CD4+CD38+HLA-DR+ T cell frequency was associated with decreased carotid artery distensibility (β= -2.00, 95{\%} confidence interval [CI] = -3.86, -0.14, P= 0.04) and increased Young's modulus (β= 1.00, 95{\%} CI = 0.03, 1.97, P= 0.04). These associations were affected little by further adjustment for CD4+ T cell count and viral load. Among HIV-infected women, higher frequencies of immunosenescent T cells, including CD4+CD28-CD57+ and CD8+CD28-CD57+ T cells, were also associated with decreased arterial distensibility. Among HIV-uninfected women, frequencies of activated or senescent T cells were not significantly associated with measures of carotid stiffness. Discussion: T cell activation and senescence are associated with arterial stiffness, suggesting that pro-inflammatory populations of T cells may produce functional or structural vascular changes in HIV-infected women.",
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AU - Sinclair, Elizabeth

AU - Landay, Alan L.

AU - Lurain, Nell

AU - Sharrett, A. Richey

AU - Gange, Stephen J.

AU - Xue, Xiaonan (Nan)

AU - Parrinello, Christina M.

AU - Hunt, Peter

AU - Deeks, Steven G.

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N2 - Objectives: HIV disease is associated with increased arterial stiffness, which may be related to inflammation provoked by HIV-related immune perturbation. We assessed the association of T cell markers of immune activation and immunosenescence with carotid artery stiffness among HIV-infected women. Methods: Among 114 HIV-infected and 43 HIV-uninfected women, we measured CD4+ and CD8+ T cell populations expressing activation (CD38+HLA-DR+) and senescence (CD28-CD57+) markers. We then related these measures of immune status with parameters of carotid artery stiffness, including decreased distensibility, and increased Young's elastic modulus, as assessed by B-mode ultrasound. Results: HIV infection was associated with increased CD4+ T cell activation, CD8+ T cell activation and CD8+ T cell senescence. Among HIV-infected women, adjusted for age, HIV medications, and vascular risk factors, higher CD4+CD38+HLA-DR+ T cell frequency was associated with decreased carotid artery distensibility (β= -2.00, 95% confidence interval [CI] = -3.86, -0.14, P= 0.04) and increased Young's modulus (β= 1.00, 95% CI = 0.03, 1.97, P= 0.04). These associations were affected little by further adjustment for CD4+ T cell count and viral load. Among HIV-infected women, higher frequencies of immunosenescent T cells, including CD4+CD28-CD57+ and CD8+CD28-CD57+ T cells, were also associated with decreased arterial distensibility. Among HIV-uninfected women, frequencies of activated or senescent T cells were not significantly associated with measures of carotid stiffness. Discussion: T cell activation and senescence are associated with arterial stiffness, suggesting that pro-inflammatory populations of T cells may produce functional or structural vascular changes in HIV-infected women.

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