T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women

Robert C. Kaplan, Elizabeth Sinclair, Alan L. Landay, Nell Lurain, A. Richey Sharrett, Stephen J. Gange, Xiaonan (Nan) Xue, Peter Hunt, Roksana Karim, David M. Kern, Howard N. Hodis, Steven G. Deeks

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Abstract

Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults. Methods. T cell phenotyping and carotid ultrasound were assessed among 115 HIV-infected women and 43 age- and race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency HIV Study. Multivariate analyses were used to assess the association of T cell activation (CD38+HLA-DR+) and senescence (CD28-CD57+) with subclinical carotid artery disease. Results. Compared with HIV-uninfected women, frequencies of CD4 +CD38+HLA-DR+, CD8+CD38 +HLA-DR +, and CD8+CD28-CD57 + T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. Among HIV-infected women, adjusted for age, antiretroviral medications, and viral load, higher frequencies of activated CD4+ and CD8+ T cells and immunosenescent CD8+ T cells were associated with increased prevalence of carotid artery lesions (prevalence ratiolesions associated with activated CD4+ T cells, 1.6 per SD [95% confidence interval {CI}, 1.1-2.2]; P = .02; prevalence ratiolesions associated with activated CD8+ T cells, 2.0 per SD [95% CI, 1.2-3.3]; P < .01; prevalence ratiolesions associated with senescent CD8 + T cells, 1.9 per SD [95% CI, 1.1-3.1]; P = .01). Conclusions. HIV-associated T cell changes are associated with subclinical carotid artery abnormalities, which may be observed even among those patients achieving viral suppression with effective antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)452-463
Number of pages12
JournalJournal of Infectious Diseases
Volume203
Issue number4
DOIs
StatePublished - Feb 15 2011

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Carotid Artery Diseases
Cell Aging
HIV
T-Lymphocytes
HLA-DR Antigens
Confidence Intervals
Carotid Arteries
Virus Diseases
Viral Load
Vascular Diseases
Multivariate Analysis

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Kaplan, R. C., Sinclair, E., Landay, A. L., Lurain, N., Sharrett, A. R., Gange, S. J., ... Deeks, S. G. (2011). T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. Journal of Infectious Diseases, 203(4), 452-463. https://doi.org/10.1093/infdis/jiq071

T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. / Kaplan, Robert C.; Sinclair, Elizabeth; Landay, Alan L.; Lurain, Nell; Sharrett, A. Richey; Gange, Stephen J.; Xue, Xiaonan (Nan); Hunt, Peter; Karim, Roksana; Kern, David M.; Hodis, Howard N.; Deeks, Steven G.

In: Journal of Infectious Diseases, Vol. 203, No. 4, 15.02.2011, p. 452-463.

Research output: Contribution to journalArticle

Kaplan, RC, Sinclair, E, Landay, AL, Lurain, N, Sharrett, AR, Gange, SJ, Xue, XN, Hunt, P, Karim, R, Kern, DM, Hodis, HN & Deeks, SG 2011, 'T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women', Journal of Infectious Diseases, vol. 203, no. 4, pp. 452-463. https://doi.org/10.1093/infdis/jiq071
Kaplan, Robert C. ; Sinclair, Elizabeth ; Landay, Alan L. ; Lurain, Nell ; Sharrett, A. Richey ; Gange, Stephen J. ; Xue, Xiaonan (Nan) ; Hunt, Peter ; Karim, Roksana ; Kern, David M. ; Hodis, Howard N. ; Deeks, Steven G. / T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. In: Journal of Infectious Diseases. 2011 ; Vol. 203, No. 4. pp. 452-463.
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abstract = "Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults. Methods. T cell phenotyping and carotid ultrasound were assessed among 115 HIV-infected women and 43 age- and race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency HIV Study. Multivariate analyses were used to assess the association of T cell activation (CD38+HLA-DR+) and senescence (CD28-CD57+) with subclinical carotid artery disease. Results. Compared with HIV-uninfected women, frequencies of CD4 +CD38+HLA-DR+, CD8+CD38 +HLA-DR +, and CD8+CD28-CD57 + T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. Among HIV-infected women, adjusted for age, antiretroviral medications, and viral load, higher frequencies of activated CD4+ and CD8+ T cells and immunosenescent CD8+ T cells were associated with increased prevalence of carotid artery lesions (prevalence ratiolesions associated with activated CD4+ T cells, 1.6 per SD [95{\%} confidence interval {CI}, 1.1-2.2]; P = .02; prevalence ratiolesions associated with activated CD8+ T cells, 2.0 per SD [95{\%} CI, 1.2-3.3]; P < .01; prevalence ratiolesions associated with senescent CD8 + T cells, 1.9 per SD [95{\%} CI, 1.1-3.1]; P = .01). Conclusions. HIV-associated T cell changes are associated with subclinical carotid artery abnormalities, which may be observed even among those patients achieving viral suppression with effective antiretroviral therapy.",
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T1 - T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women

AU - Kaplan, Robert C.

AU - Sinclair, Elizabeth

AU - Landay, Alan L.

AU - Lurain, Nell

AU - Sharrett, A. Richey

AU - Gange, Stephen J.

AU - Xue, Xiaonan (Nan)

AU - Hunt, Peter

AU - Karim, Roksana

AU - Kern, David M.

AU - Hodis, Howard N.

AU - Deeks, Steven G.

PY - 2011/2/15

Y1 - 2011/2/15

N2 - Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults. Methods. T cell phenotyping and carotid ultrasound were assessed among 115 HIV-infected women and 43 age- and race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency HIV Study. Multivariate analyses were used to assess the association of T cell activation (CD38+HLA-DR+) and senescence (CD28-CD57+) with subclinical carotid artery disease. Results. Compared with HIV-uninfected women, frequencies of CD4 +CD38+HLA-DR+, CD8+CD38 +HLA-DR +, and CD8+CD28-CD57 + T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. Among HIV-infected women, adjusted for age, antiretroviral medications, and viral load, higher frequencies of activated CD4+ and CD8+ T cells and immunosenescent CD8+ T cells were associated with increased prevalence of carotid artery lesions (prevalence ratiolesions associated with activated CD4+ T cells, 1.6 per SD [95% confidence interval {CI}, 1.1-2.2]; P = .02; prevalence ratiolesions associated with activated CD8+ T cells, 2.0 per SD [95% CI, 1.2-3.3]; P < .01; prevalence ratiolesions associated with senescent CD8 + T cells, 1.9 per SD [95% CI, 1.1-3.1]; P = .01). Conclusions. HIV-associated T cell changes are associated with subclinical carotid artery abnormalities, which may be observed even among those patients achieving viral suppression with effective antiretroviral therapy.

AB - Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae of HIV infection, are associated with vascular disease among HIV-infected adults. Methods. T cell phenotyping and carotid ultrasound were assessed among 115 HIV-infected women and 43 age- and race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency HIV Study. Multivariate analyses were used to assess the association of T cell activation (CD38+HLA-DR+) and senescence (CD28-CD57+) with subclinical carotid artery disease. Results. Compared with HIV-uninfected women, frequencies of CD4 +CD38+HLA-DR+, CD8+CD38 +HLA-DR +, and CD8+CD28-CD57 + T cells were higher among HIV-infected women, including those who achieved viral suppression while receiving antiretroviral treatment. Among HIV-infected women, adjusted for age, antiretroviral medications, and viral load, higher frequencies of activated CD4+ and CD8+ T cells and immunosenescent CD8+ T cells were associated with increased prevalence of carotid artery lesions (prevalence ratiolesions associated with activated CD4+ T cells, 1.6 per SD [95% confidence interval {CI}, 1.1-2.2]; P = .02; prevalence ratiolesions associated with activated CD8+ T cells, 2.0 per SD [95% CI, 1.2-3.3]; P < .01; prevalence ratiolesions associated with senescent CD8 + T cells, 1.9 per SD [95% CI, 1.1-3.1]; P = .01). Conclusions. HIV-associated T cell changes are associated with subclinical carotid artery abnormalities, which may be observed even among those patients achieving viral suppression with effective antiretroviral therapy.

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