Abstract
Metastatic breast cancer requires systemic treatment. We have developed a systemic gene therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5-10 times higher than the common nonviral agents Fugene-6 and Lipofectamine in the presence of serum. The SN-bik gene complex induced significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer cells implanted in nude mice and prolonged the life span of the treated animals. This study demonstrates that SN-bik is a promising approach for further development as a potential therapeutic agent of cancer.
Original language | English (US) |
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Pages (from-to) | 8-12 |
Number of pages | 5 |
Journal | Cancer research |
Volume | 62 |
Issue number | 1 |
State | Published - Jan 1 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research