Systemic tumor suppression by the proapoptotic gene bik

Yiyu Zou, Hua Peng, Binhua Zhou, Yong Wen, Shao Chun Wang, Eing Mei Tsai, Mien Chie Hung

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Metastatic breast cancer requires systemic treatment. We have developed a systemic gene therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5-10 times higher than the common nonviral agents Fugene-6 and Lipofectamine in the presence of serum. The SN-bik gene complex induced significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer cells implanted in nude mice and prolonged the life span of the treated animals. This study demonstrates that SN-bik is a promising approach for further development as a potential therapeutic agent of cancer.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalCancer research
Volume62
Issue number1
StatePublished - Jan 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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