Systemic tumor suppression by the proapoptotic gene bik

Yiyu Zou, Hua Peng, Binhua Zhou, Yong Wen, Shao Chun Wang, Eing Mei Tsai, Mien Chie Hung

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Metastatic breast cancer requires systemic treatment. We have developed a systemic gene therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5-10 times higher than the common nonviral agents Fugene-6 and Lipofectamine in the presence of serum. The SN-bik gene complex induced significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer cells implanted in nude mice and prolonged the life span of the treated animals. This study demonstrates that SN-bik is a promising approach for further development as a potential therapeutic agent of cancer.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalCancer Research
Volume62
Issue number1
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

Breast Neoplasms
Nude Mice
Genes
Neoplasms
Gene Transfer Techniques
Reporter Genes
Genetic Therapy
Transfection
Apoptosis
Neoplasm Metastasis
Cell Line
Therapeutics
Growth
Serum
Lipofectamine
In Vitro Techniques
FuGene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Zou, Y., Peng, H., Zhou, B., Wen, Y., Wang, S. C., Tsai, E. M., & Hung, M. C. (2002). Systemic tumor suppression by the proapoptotic gene bik. Cancer Research, 62(1), 8-12.

Systemic tumor suppression by the proapoptotic gene bik. / Zou, Yiyu; Peng, Hua; Zhou, Binhua; Wen, Yong; Wang, Shao Chun; Tsai, Eing Mei; Hung, Mien Chie.

In: Cancer Research, Vol. 62, No. 1, 01.01.2002, p. 8-12.

Research output: Contribution to journalArticle

Zou, Y, Peng, H, Zhou, B, Wen, Y, Wang, SC, Tsai, EM & Hung, MC 2002, 'Systemic tumor suppression by the proapoptotic gene bik', Cancer Research, vol. 62, no. 1, pp. 8-12.
Zou Y, Peng H, Zhou B, Wen Y, Wang SC, Tsai EM et al. Systemic tumor suppression by the proapoptotic gene bik. Cancer Research. 2002 Jan 1;62(1):8-12.
Zou, Yiyu ; Peng, Hua ; Zhou, Binhua ; Wen, Yong ; Wang, Shao Chun ; Tsai, Eing Mei ; Hung, Mien Chie. / Systemic tumor suppression by the proapoptotic gene bik. In: Cancer Research. 2002 ; Vol. 62, No. 1. pp. 8-12.
@article{a824bd282f9440669573d829d6519379,
title = "Systemic tumor suppression by the proapoptotic gene bik",
abstract = "Metastatic breast cancer requires systemic treatment. We have developed a systemic gene therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5-10 times higher than the common nonviral agents Fugene-6 and Lipofectamine in the presence of serum. The SN-bik gene complex induced significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer cells implanted in nude mice and prolonged the life span of the treated animals. This study demonstrates that SN-bik is a promising approach for further development as a potential therapeutic agent of cancer.",
author = "Yiyu Zou and Hua Peng and Binhua Zhou and Yong Wen and Wang, {Shao Chun} and Tsai, {Eing Mei} and Hung, {Mien Chie}",
year = "2002",
month = "1",
day = "1",
language = "English (US)",
volume = "62",
pages = "8--12",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "1",

}

TY - JOUR

T1 - Systemic tumor suppression by the proapoptotic gene bik

AU - Zou, Yiyu

AU - Peng, Hua

AU - Zhou, Binhua

AU - Wen, Yong

AU - Wang, Shao Chun

AU - Tsai, Eing Mei

AU - Hung, Mien Chie

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Metastatic breast cancer requires systemic treatment. We have developed a systemic gene therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5-10 times higher than the common nonviral agents Fugene-6 and Lipofectamine in the presence of serum. The SN-bik gene complex induced significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer cells implanted in nude mice and prolonged the life span of the treated animals. This study demonstrates that SN-bik is a promising approach for further development as a potential therapeutic agent of cancer.

AB - Metastatic breast cancer requires systemic treatment. We have developed a systemic gene therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5-10 times higher than the common nonviral agents Fugene-6 and Lipofectamine in the presence of serum. The SN-bik gene complex induced significant apoptosis in four breast cancer cell lines in vitro as well as in orthotopic tumor tissues in nude mice. Systemically administrated SN-bik significantly inhibited the growth and metastasis of human breast cancer cells implanted in nude mice and prolonged the life span of the treated animals. This study demonstrates that SN-bik is a promising approach for further development as a potential therapeutic agent of cancer.

UR - http://www.scopus.com/inward/record.url?scp=0036142925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036142925&partnerID=8YFLogxK

M3 - Article

VL - 62

SP - 8

EP - 12

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 1

ER -