Systemic mastocytosis in a child with t(8;21) acute myeloid leukemia

Kris M. Mahadeo, Lucia Wolgast, Christine Mcmahon, Peter D. Cole

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Mastocytosis is primarily limited to the cutaneous variant in pediatric patients. Systemic mastocytosis (SM) has been associated with t(8;21) acute myeloid leukemia (AML) in adults. We provide the first report of a child with t(8;21) AML, diagnosed with asymptomatic SM following four cycles of chemotherapy. Unlike most adults with SM/AML, she was not found to have a c-KIT (D816V) mutation. SM persisted in the bone marrow after completion of chemotherapy, and her AML relapsed 9 months off-treatment. Although she achieved a second remission, mastocytosis persists in the marrow. Pediatric patients with t(8;21) AML/SM may represent a high-risk group despite favorable cytogenetics.

Original languageEnglish (US)
Pages (from-to)684-687
Number of pages4
JournalPediatric Blood and Cancer
Volume57
Issue number4
DOIs
Publication statusPublished - Oct 1 2011

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Keywords

  • AML
  • Molecular diagnosis and therapy
  • Pediatric hematology/oncology
  • Systemic mastocytosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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