Systemic inflammatory response does not correlate with acute lung injury associated with mechanical ventilation strategies in normal lungs

Caron M. Hong, Da Zhong Xu, Qi Lu, Yunhui Cheng, Vadim Pisarenko, Danielle Doucet, Margaret Brown, Chunxiang Zhang, Edwin A. Deitch, Ellise Delphin

Research output: Contribution to journalArticle

Abstract

BACKGROUND:: Mechanical ventilation (MV) can lead to ventilator-induced lung injury secondary to trauma and associated increases in pulmonary inflammatory cytokines. There is controversy regarding the associated systemic inflammatory response. In this report, we demonstrate the effects of MV on systemic inflammation. METHODS:: This report is part of a previously published study (Hong et al. Anesth Analg 2010;110:1652-60). Female pigs were randomized into 3 groups. Group H-VT/3 was ventilated with a tidal volume (VT) of 15 mL/kg predicted body weight (PBW)/positive end-expiratory pressure (PEEP) of 3 cm H2O; group L-VT/3 with a VT of 6 mL/kg PBW/PEEP of 3 cm H2O; and group L-VT/10 with a VT of 6 mL/kg PBW/PEEP of 10 cm H2O, for 8 hours. Each group had 6 subjects (n = 6). Prelung and postlung sera were analyzed for inflammatory markers. Hemodynamics, airway mechanics, and arterial blood gases were monitored. RESULTS:: There were no significant differences in systemic cytokines among groups. There were similar trends of serum inflammatory markers in all subjects. This is in contrast to findings previously published demonstrating increases in inflammatory mediators in bronchoalveolar lavage. CONCLUSION:: Systemic inflammatory markers did not correlate with lung injury associated with MV.

Original languageEnglish (US)
Pages (from-to)118-121
Number of pages4
JournalAnesthesia and analgesia
Volume115
Issue number1
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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