System-specific neurodegeneration following glucotoxicity in the C. elegans model

Adi Pinkas, Michael Lawes, Michael Aschner

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Hyperglycemia-related neuropathy leads to the onset and exacerbation of several pathologies. The C. elegans model has been used to study this phenomenon and its underlying mechanisms using a broad evaluation for neurodegeneration. Here, we report a system-specific susceptibility for glucotoxicity, namely the dopaminergic, glutamatergic and cholinergic system. Under high-glucose conditions, these systems (and not the serotonergic or GABAergic) were impaired, as observed by evaluating the fluorescent signal in GFP-tagged worm strains. The significance and implications of unequal susceptibility for glucotoxicity in the nervous system is discussed.

Original languageEnglish (US)
Pages (from-to)88-90
Number of pages3
JournalNeurotoxicology
Volume68
DOIs
StatePublished - Sep 2018

Keywords

  • Advanced glycation end products
  • C. elegans
  • Glucose
  • Neurodegeneration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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