System-specific neurodegeneration following glucotoxicity in the C. elegans model

Adi Pinkas, Michael Lawes, Michael Aschner

Research output: Contribution to journalArticle

Abstract

Hyperglycemia-related neuropathy leads to the onset and exacerbation of several pathologies. The C. elegans model has been used to study this phenomenon and its underlying mechanisms using a broad evaluation for neurodegeneration. Here, we report a system-specific susceptibility for glucotoxicity, namely the dopaminergic, glutamatergic and cholinergic system. Under high-glucose conditions, these systems (and not the serotonergic or GABAergic) were impaired, as observed by evaluating the fluorescent signal in GFP-tagged worm strains. The significance and implications of unequal susceptibility for glucotoxicity in the nervous system is discussed.

Original languageEnglish (US)
Pages (from-to)88-90
Number of pages3
JournalNeuroToxicology
Volume68
DOIs
StatePublished - Sep 1 2018

Fingerprint

Neurology
Pathology
Hyperglycemia
Cholinergic Agents
Nervous System
Glucose

Keywords

  • Advanced glycation end products
  • C. elegans
  • Glucose
  • Neurodegeneration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

System-specific neurodegeneration following glucotoxicity in the C. elegans model. / Pinkas, Adi; Lawes, Michael; Aschner, Michael.

In: NeuroToxicology, Vol. 68, 01.09.2018, p. 88-90.

Research output: Contribution to journalArticle

@article{a064efe8a5f34670b2a2c3d427efaae3,
title = "System-specific neurodegeneration following glucotoxicity in the C. elegans model",
abstract = "Hyperglycemia-related neuropathy leads to the onset and exacerbation of several pathologies. The C. elegans model has been used to study this phenomenon and its underlying mechanisms using a broad evaluation for neurodegeneration. Here, we report a system-specific susceptibility for glucotoxicity, namely the dopaminergic, glutamatergic and cholinergic system. Under high-glucose conditions, these systems (and not the serotonergic or GABAergic) were impaired, as observed by evaluating the fluorescent signal in GFP-tagged worm strains. The significance and implications of unequal susceptibility for glucotoxicity in the nervous system is discussed.",
keywords = "Advanced glycation end products, C. elegans, Glucose, Neurodegeneration",
author = "Adi Pinkas and Michael Lawes and Michael Aschner",
year = "2018",
month = "9",
day = "1",
doi = "10.1016/j.neuro.2018.07.005",
language = "English (US)",
volume = "68",
pages = "88--90",
journal = "NeuroToxicology",
issn = "0161-813X",
publisher = "Elsevier",

}

TY - JOUR

T1 - System-specific neurodegeneration following glucotoxicity in the C. elegans model

AU - Pinkas, Adi

AU - Lawes, Michael

AU - Aschner, Michael

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Hyperglycemia-related neuropathy leads to the onset and exacerbation of several pathologies. The C. elegans model has been used to study this phenomenon and its underlying mechanisms using a broad evaluation for neurodegeneration. Here, we report a system-specific susceptibility for glucotoxicity, namely the dopaminergic, glutamatergic and cholinergic system. Under high-glucose conditions, these systems (and not the serotonergic or GABAergic) were impaired, as observed by evaluating the fluorescent signal in GFP-tagged worm strains. The significance and implications of unequal susceptibility for glucotoxicity in the nervous system is discussed.

AB - Hyperglycemia-related neuropathy leads to the onset and exacerbation of several pathologies. The C. elegans model has been used to study this phenomenon and its underlying mechanisms using a broad evaluation for neurodegeneration. Here, we report a system-specific susceptibility for glucotoxicity, namely the dopaminergic, glutamatergic and cholinergic system. Under high-glucose conditions, these systems (and not the serotonergic or GABAergic) were impaired, as observed by evaluating the fluorescent signal in GFP-tagged worm strains. The significance and implications of unequal susceptibility for glucotoxicity in the nervous system is discussed.

KW - Advanced glycation end products

KW - C. elegans

KW - Glucose

KW - Neurodegeneration

UR - http://www.scopus.com/inward/record.url?scp=85050380689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050380689&partnerID=8YFLogxK

U2 - 10.1016/j.neuro.2018.07.005

DO - 10.1016/j.neuro.2018.07.005

M3 - Article

C2 - 30036563

AN - SCOPUS:85050380689

VL - 68

SP - 88

EP - 90

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

ER -