Synthesis of transition state inhibitors for N-riboside hydrolases and transferases

Richard H. Furneaux, Gerrit Limberg, Peter C. Tyler, Vern L. Schramm

Research output: Contribution to journalArticle

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Abstract

A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been synthesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4.

Original languageEnglish (US)
Pages (from-to)2915-2930
Number of pages16
JournalTetrahedron
Volume53
Issue number8
DOIs
Publication statusPublished - Feb 24 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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