TY - JOUR
T1 - Synthesis of transition state inhibitors for N-riboside hydrolases and transferases
AU - Furneaux, Richard H.
AU - Limberg, Gerrit
AU - Tyler, Peter C.
AU - Schramm, Vern L.
N1 - Funding Information:
This work was supported by research grants AI 34342 and GM 41916 from the National Institute of Health, USA and by the New Zealand Foundation for Research Science and Technology, contract C08301. Dr Herbert Wong is thanked for a superb n.mr. service.
PY - 1997/2/24
Y1 - 1997/2/24
N2 - A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been synthesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4.
AB - A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been synthesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4.
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U2 - 10.1016/S0040-4020(96)01172-6
DO - 10.1016/S0040-4020(96)01172-6
M3 - Article
AN - SCOPUS:0031584878
VL - 53
SP - 2915
EP - 2930
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 8
ER -