TY - JOUR
T1 - Synthesis of transition state inhibitors for N-riboside hydrolases and transferases
AU - Furneaux, Richard H.
AU - Limberg, Gerrit
AU - Tyler, Peter C.
AU - Schramm, Vern L.
PY - 1997/2/24
Y1 - 1997/2/24
N2 - A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been synthesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4.
AB - A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been synthesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4.
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U2 - 10.1016/S0040-4020(96)01172-6
DO - 10.1016/S0040-4020(96)01172-6
M3 - Article
AN - SCOPUS:0031584878
VL - 53
SP - 2915
EP - 2930
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 8
ER -