Synthesis of immunoglobulin by substrate attached mouse myeloma cells

Antonio Bargellesi, Guido Damiani, W. Michael Kuehl, Matthew D. Scharff

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Cultured mouse myeloma cells grow in suspension and synthesize and secrete large amounts of immunoglobulin. Mouse myeloma cells which attach to a plastic substratum have been obtained by mutagenesis and subsequent selection. Normal mouse myeloma cells will also attach to plastic tissue culture dishes pre‐treated with poly‐L‐lysine. The attached cells synthesize and secrete the same large amounts of immunoglobulin as the suspended cells.

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalJournal of Cellular Physiology
Volume88
Issue number2
DOIs
StatePublished - Jun 1976

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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