Synthesis of aminomethyl and amino analogs of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine

Shih Hsi Chu; Zhi Hao Chen; Zun Yao Weng; Elizabeth C. Rowe; Edward Chu; Ming‐Yu Wang Chu

doi:10.1002/jhet.5570240418

Synthesis of aminomethyl and amino analogs of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine

Shih Hsi Chu, Zhi Hao Chen, Zun Yao Weng, Elizabeth C. Rowe, Edward Chu, Ming‐Yu Wang Chu

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Amino analogs of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacyclouridine) and their 2′‐hydroxymethyl derivatives were synthesized for evaluation as inhibitors of uridine phosphorylase and hence potential cancer chemotherapeutic agents. Both aminomethyl analogs were found to be potent inhibitors of this enzyme and good potentiators of the anti‐tumor action of FUdR.

Original language	English (US)
Pages (from-to)	989-995
Number of pages	7
Journal	Journal of Heterocyclic Chemistry
Volume	24
Issue number	4
DOIs	https://doi.org/10.1002/jhet.5570240418
State	Published - 1987
Externally published	Yes

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Organic Chemistry

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10.1002/jhet.5570240418

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title = "Synthesis of aminomethyl and amino analogs of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine",

abstract = "Amino analogs of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacyclouridine) and their 2′‐hydroxymethyl derivatives were synthesized for evaluation as inhibitors of uridine phosphorylase and hence potential cancer chemotherapeutic agents. Both aminomethyl analogs were found to be potent inhibitors of this enzyme and good potentiators of the anti‐tumor action of FUdR.",

author = "Chu, {Shih Hsi} and Chen, {Zhi Hao} and Weng, {Zun Yao} and Rowe, {Elizabeth C.} and Edward Chu and Chu, {Ming‐Yu Wang}",

year = "1987",

doi = "10.1002/jhet.5570240418",

language = "English (US)",

volume = "24",

pages = "989--995",

journal = "Journal of Heterocyclic Chemistry",

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TY - JOUR

T1 - Synthesis of aminomethyl and amino analogs of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine

AU - Chu, Shih Hsi

AU - Chen, Zhi Hao

AU - Weng, Zun Yao

AU - Rowe, Elizabeth C.

AU - Chu, Edward

AU - Chu, Ming‐Yu Wang

PY - 1987

Y1 - 1987

N2 - Amino analogs of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacyclouridine) and their 2′‐hydroxymethyl derivatives were synthesized for evaluation as inhibitors of uridine phosphorylase and hence potential cancer chemotherapeutic agents. Both aminomethyl analogs were found to be potent inhibitors of this enzyme and good potentiators of the anti‐tumor action of FUdR.

AB - Amino analogs of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacyclouridine) and their 2′‐hydroxymethyl derivatives were synthesized for evaluation as inhibitors of uridine phosphorylase and hence potential cancer chemotherapeutic agents. Both aminomethyl analogs were found to be potent inhibitors of this enzyme and good potentiators of the anti‐tumor action of FUdR.

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U2 - 10.1002/jhet.5570240418

DO - 10.1002/jhet.5570240418

M3 - Article

AN - SCOPUS:0023180233

SN - 0022-152X

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SP - 989

EP - 995

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 4

ER -

Synthesis of aminomethyl and amino analogs of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine

Abstract

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