Synthesis of aminomethyl and amino analogs of 5‐benzylacyclouridine and 5‐benzyloxybenzylacyclouridine

Shih Hsi Chu, Zhi Hao Chen, Zun Yao Weng, Elizabeth C. Rowe, Edward Chu, Ming‐Yu Wang Chu

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Amino analogs of BAU (5‐benzylacyclouridine) and BBAU (5‐benzyloxybenzylacyclouridine) and their 2′‐hydroxymethyl derivatives were synthesized for evaluation as inhibitors of uridine phosphorylase and hence potential cancer chemotherapeutic agents. Both aminomethyl analogs were found to be potent inhibitors of this enzyme and good potentiators of the anti‐tumor action of FUdR.

Original languageEnglish (US)
Pages (from-to)989-995
Number of pages7
JournalJournal of Heterocyclic Chemistry
Volume24
Issue number4
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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