Synthesis of 5′-methylthio coformycins: Specific inhibitors for malarial adenosine deaminase

Medicine & Life Sciences

• Coformycin 86%
• Adenosine Deaminase Inhibitors 72%
• Plasmodium falciparum 48%
• Adenosine Deaminase 34%
• 5'-methylthioadenosine 32%
• purine 31%
• Pentostatin 27%
• Deamination 24%
• Parasites 22%
• Cattle 22%
• Enzymes 20%
• Adenosine 18%
• human ADA protein 16%
• Substrate Specificity 10%
• Biological Products 9%
• Acceleration 8%
• Malaria 8%
• Cats 7%
• Poisons 6%

Chemical Compounds

• Coformycins 100%
• Adenosine 43%
• Transition State 26%
• Purine 19%
• Deamination 15%
• Dissociation Constant 12%
• Coformycin 11%
• EC 3.5.4.4 (Adenosine Deaminase) Inhibitor 11%
• Antimalarial 7%
• Transition State Theory 7%
• Binding Energy 5%
• Occurrence in Nature 5%
• Toxic 4%
• Energy 3%

Engineering & Materials Science

• Enzymes 52%
• Parasites 49%
• Salvaging 48%
• Enzyme inhibition 20%
• Stabilization 19%
• Binding energy 18%
• Availability 8%
• Substrates 8%
• Geometry 6%