Synthesis of 5-benzyl and 5-benzyloxybenzyl 2,2'-anhydroudridines and related nucleoside analogs as inhibitors of uridine phosphorylase

Shih Hsi Chu, Zun Yao Weng, Zhi Hao Chen, Elizabeth C. Rowe, Edward Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni, Sungnan Cha, Ming Y. Chu

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Furanosyl analogs of BAU (5-benzylacyclouridine) and BBAU (5-benzyloxybenzylacyclouridine), two potent inhibitors of uridine phosphorylase, were synthesized and evaluated as potential cancer chemotherapeutic agents. The analogs included ribosides, 2,2'-anhydro nucleosides, arabinosides and deoxyribosides. The anhydrouridine intermediates were potent inhibitors of uridine phosphorylase and good potentiators of FdUrd activity in hunan tumor cells in culture.

Original languageEnglish (US)
Pages (from-to)91-102
Number of pages12
JournalNucleosides and Nucleotides
Volume7
Issue number1
DOIs
StatePublished - Jan 2 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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