Abstract
Furanosyl analogs of BAU (5-benzylacyclouridine) and BBAU (5-benzyloxybenzylacyclouridine), two potent inhibitors of uridine phosphorylase, were synthesized and evaluated as potential cancer chemotherapeutic agents. The analogs included ribosides, 2,2'-anhydro nucleosides, arabinosides and deoxyribosides. The anhydrouridine intermediates were potent inhibitors of uridine phosphorylase and good potentiators of FdUrd activity in hunan tumor cells in culture.
Original language | English (US) |
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Pages (from-to) | 91-102 |
Number of pages | 12 |
Journal | Nucleosides and Nucleotides |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Genetics