Synthesis and characterization of a series of hydrophobic antitumor bis(carboxylato) (1, 2-diaminocyclohexane) platinum(ii) complexes

Salaam Al-Baker; Roman Perez-Soler; Abdul R. Khokhar

doi:10.1080/00958979308037119

Synthesis and characterization of a series of hydrophobic antitumor bis(carboxylato) (1, 2-diaminocyclohexane) platinum(ii) complexes

Salaam Al-Baker, Roman Perez-Soler, Abdul R. Khokhar

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A series of hydrophobic platinum(II) complexes of the type (DACH)PtX₂(where DACH = various isomeric forms of 1, 2-diaminocyclohexane and X = pentanoato, hexanoato, heptanoato, octanoato, nonanoato, decanoato, unidecanoato, laurato, tridecanoato, myristato, pentadecanoato, palmitato, heptadecanoato, or stearato) has been synthesized and characterized using elemental analysis, infrared spectra and nuclear magnetic resonance (¹³C{¹H} and¹⁹⁵Pt{¹H}). The complexes have been prepared as potential antitumor agents for liposome entrapment.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Journal of Coordination Chemistry
Volume	29
Issue number	1-2
DOIs	https://doi.org/10.1080/00958979308037119
State	Published - Jun 1 1993
Externally published	Yes

Keywords

2-diaminocyclohexane carboxylate liposomes hydrophobic synthesis
Platinum 1

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Materials Chemistry

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10.1080/00958979308037119

Cite this

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AU - Al-Baker, Salaam

AU - Perez-Soler, Roman

AU - Khokhar, Abdul R.

PY - 1993/6/1

Y1 - 1993/6/1

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AB - A series of hydrophobic platinum(II) complexes of the type (DACH)PtX2(where DACH = various isomeric forms of 1, 2-diaminocyclohexane and X = pentanoato, hexanoato, heptanoato, octanoato, nonanoato, decanoato, unidecanoato, laurato, tridecanoato, myristato, pentadecanoato, palmitato, heptadecanoato, or stearato) has been synthesized and characterized using elemental analysis, infrared spectra and nuclear magnetic resonance (13C{1H} and195Pt{1H}). The complexes have been prepared as potential antitumor agents for liposome entrapment.

KW - 2-diaminocyclohexane carboxylate liposomes hydrophobic synthesis

KW - Platinum 1

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Synthesis and characterization of a series of hydrophobic antitumor bis(carboxylato) (1, 2-diaminocyclohexane) platinum(ii) complexes

Abstract

Keywords

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