Synthesis and characterization of a series of hydrophobic antitumor bis(carboxylato) (1, 2-diaminocyclohexane) platinum(ii) complexes

Salaam Al-Baker, Roman Perez-Soler, Abdul R. Khokhar

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A series of hydrophobic platinum(II) complexes of the type (DACH)PtX2(where DACH = various isomeric forms of 1, 2-diaminocyclohexane and X = pentanoato, hexanoato, heptanoato, octanoato, nonanoato, decanoato, unidecanoato, laurato, tridecanoato, myristato, pentadecanoato, palmitato, heptadecanoato, or stearato) has been synthesized and characterized using elemental analysis, infrared spectra and nuclear magnetic resonance (13C{1H} and195Pt{1H}). The complexes have been prepared as potential antitumor agents for liposome entrapment.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Coordination Chemistry
Volume29
Issue number1-2
DOIs
StatePublished - Jun 1 1993
Externally publishedYes

Keywords

  • 2-diaminocyclohexane carboxylate liposomes hydrophobic synthesis
  • Platinum 1

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry

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