Synthesis and breakdown of fibrillar collagens: Concomitant phenomena in ovarian cancer

M. Santala, J. Risteli, L. Risteli, U. Puistola, B. M. Kacinski, E. R. Stanley, A. Kauppila

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The synthesis and degradation of type I and type III interstitial collagens releases several antigenic metabolites, whose measurement allows the metabolism of connective tissue to be evaluated under a variety of different conditions. In this study we investigated the influence of benign and malignant ovarian neoplasms on the metabolism of these collagens. The study population comprised patients with benign (n = 53), borderline (n = 6) or malignant (n = 36) ovarian neoplasms. We quantified the serum, cyst fluid and peritoneal/ascitic fluid concentrations of the amino-terminal propeptide of type I (PINP) and III (PIIINP) procollagens, indicators of the synthesis of type I and III collagen, respectively and the cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), an indicator of type I collagen degradation. Macrophage colony-stimulating factor 1 (CSF-1) concentration was also assayed as its serum level is increased in ovarian cancer and CSF-1 may be involved in the regulation of collagen metabolism. The concentration of each antigen was significantly higher in patients with malignant tumour than with benign neoplasm in each comparison, except for ICTP in peritoneal fluid and for CSF-1 in cyst fluid. The high ascitic fluid concentration of PINP, PIIINP or CSF-1 correlated with malignancy, and the low cyst fluid concentration of any of the four markers was indicative of benign tumour. Levels of CSF-1 did not correlate with the levels of any of the markers of collagen turnover. The concentration of PINP in ascites was about 50 times higher and in cyst fluid about eight times higher than that in the serum from patients with malignant tumour, whereas the respective ratios for ICTP were only 2.5 and 1.3. In such patients, the ratio of ascitic fluid to serum concentration was also about 80-fold higher for PIIINP and about 20-fold higher for PINP than for ICTP. The different distributions of PIIINP, PINP and ICTP suggests dominance of synthetic processes or retarted elimination of PIIINP and PINP in ovarian cancer. In advanced malignancies, the accumulation of PINP and PIIINP in abdominal space, possibly due to increased synthesis and/or failed resorption, may promote ascites formation. This study shows that both accelerated synthesis and breakdown of fibrillar collagens are characteristic of ovarian malignancy, and suggests that measurements of cyst fluid or ascitic fluid concentrations of collagen metabolites or CSF-1 could be used in the differential diagnosis of benign and malignant ovarian neoplasms.

Original languageEnglish (US)
Pages (from-to)1825-1831
Number of pages7
JournalBritish Journal of Cancer
Volume77
Issue number11
StatePublished - Jun 1998

Fingerprint

Fibrillar Collagens
Macrophage Colony-Stimulating Factor
Ascitic Fluid
Cyst Fluid
Ovarian Neoplasms
Collagen
Collagen Type I
Neoplasms
Collagen Type III
Serum
Ascites
Procollagen
Connective Tissue
procollagen Type III-N-terminal peptide
Differential Diagnosis
Antigens

Keywords

  • Ascites formation
  • Macrophage colony-stimulating factor 1
  • Matrix reaction
  • Tumour-associated marker
  • Type I collagen
  • Type III collagen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Santala, M., Risteli, J., Risteli, L., Puistola, U., Kacinski, B. M., Stanley, E. R., & Kauppila, A. (1998). Synthesis and breakdown of fibrillar collagens: Concomitant phenomena in ovarian cancer. British Journal of Cancer, 77(11), 1825-1831.

Synthesis and breakdown of fibrillar collagens : Concomitant phenomena in ovarian cancer. / Santala, M.; Risteli, J.; Risteli, L.; Puistola, U.; Kacinski, B. M.; Stanley, E. R.; Kauppila, A.

In: British Journal of Cancer, Vol. 77, No. 11, 06.1998, p. 1825-1831.

Research output: Contribution to journalArticle

Santala, M, Risteli, J, Risteli, L, Puistola, U, Kacinski, BM, Stanley, ER & Kauppila, A 1998, 'Synthesis and breakdown of fibrillar collagens: Concomitant phenomena in ovarian cancer', British Journal of Cancer, vol. 77, no. 11, pp. 1825-1831.
Santala M, Risteli J, Risteli L, Puistola U, Kacinski BM, Stanley ER et al. Synthesis and breakdown of fibrillar collagens: Concomitant phenomena in ovarian cancer. British Journal of Cancer. 1998 Jun;77(11):1825-1831.
Santala, M. ; Risteli, J. ; Risteli, L. ; Puistola, U. ; Kacinski, B. M. ; Stanley, E. R. ; Kauppila, A. / Synthesis and breakdown of fibrillar collagens : Concomitant phenomena in ovarian cancer. In: British Journal of Cancer. 1998 ; Vol. 77, No. 11. pp. 1825-1831.
@article{3cefaf87be3a44b3a513ad543a75e2ec,
title = "Synthesis and breakdown of fibrillar collagens: Concomitant phenomena in ovarian cancer",
abstract = "The synthesis and degradation of type I and type III interstitial collagens releases several antigenic metabolites, whose measurement allows the metabolism of connective tissue to be evaluated under a variety of different conditions. In this study we investigated the influence of benign and malignant ovarian neoplasms on the metabolism of these collagens. The study population comprised patients with benign (n = 53), borderline (n = 6) or malignant (n = 36) ovarian neoplasms. We quantified the serum, cyst fluid and peritoneal/ascitic fluid concentrations of the amino-terminal propeptide of type I (PINP) and III (PIIINP) procollagens, indicators of the synthesis of type I and III collagen, respectively and the cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), an indicator of type I collagen degradation. Macrophage colony-stimulating factor 1 (CSF-1) concentration was also assayed as its serum level is increased in ovarian cancer and CSF-1 may be involved in the regulation of collagen metabolism. The concentration of each antigen was significantly higher in patients with malignant tumour than with benign neoplasm in each comparison, except for ICTP in peritoneal fluid and for CSF-1 in cyst fluid. The high ascitic fluid concentration of PINP, PIIINP or CSF-1 correlated with malignancy, and the low cyst fluid concentration of any of the four markers was indicative of benign tumour. Levels of CSF-1 did not correlate with the levels of any of the markers of collagen turnover. The concentration of PINP in ascites was about 50 times higher and in cyst fluid about eight times higher than that in the serum from patients with malignant tumour, whereas the respective ratios for ICTP were only 2.5 and 1.3. In such patients, the ratio of ascitic fluid to serum concentration was also about 80-fold higher for PIIINP and about 20-fold higher for PINP than for ICTP. The different distributions of PIIINP, PINP and ICTP suggests dominance of synthetic processes or retarted elimination of PIIINP and PINP in ovarian cancer. In advanced malignancies, the accumulation of PINP and PIIINP in abdominal space, possibly due to increased synthesis and/or failed resorption, may promote ascites formation. This study shows that both accelerated synthesis and breakdown of fibrillar collagens are characteristic of ovarian malignancy, and suggests that measurements of cyst fluid or ascitic fluid concentrations of collagen metabolites or CSF-1 could be used in the differential diagnosis of benign and malignant ovarian neoplasms.",
keywords = "Ascites formation, Macrophage colony-stimulating factor 1, Matrix reaction, Tumour-associated marker, Type I collagen, Type III collagen",
author = "M. Santala and J. Risteli and L. Risteli and U. Puistola and Kacinski, {B. M.} and Stanley, {E. R.} and A. Kauppila",
year = "1998",
month = "6",
language = "English (US)",
volume = "77",
pages = "1825--1831",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Synthesis and breakdown of fibrillar collagens

T2 - Concomitant phenomena in ovarian cancer

AU - Santala, M.

AU - Risteli, J.

AU - Risteli, L.

AU - Puistola, U.

AU - Kacinski, B. M.

AU - Stanley, E. R.

AU - Kauppila, A.

PY - 1998/6

Y1 - 1998/6

N2 - The synthesis and degradation of type I and type III interstitial collagens releases several antigenic metabolites, whose measurement allows the metabolism of connective tissue to be evaluated under a variety of different conditions. In this study we investigated the influence of benign and malignant ovarian neoplasms on the metabolism of these collagens. The study population comprised patients with benign (n = 53), borderline (n = 6) or malignant (n = 36) ovarian neoplasms. We quantified the serum, cyst fluid and peritoneal/ascitic fluid concentrations of the amino-terminal propeptide of type I (PINP) and III (PIIINP) procollagens, indicators of the synthesis of type I and III collagen, respectively and the cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), an indicator of type I collagen degradation. Macrophage colony-stimulating factor 1 (CSF-1) concentration was also assayed as its serum level is increased in ovarian cancer and CSF-1 may be involved in the regulation of collagen metabolism. The concentration of each antigen was significantly higher in patients with malignant tumour than with benign neoplasm in each comparison, except for ICTP in peritoneal fluid and for CSF-1 in cyst fluid. The high ascitic fluid concentration of PINP, PIIINP or CSF-1 correlated with malignancy, and the low cyst fluid concentration of any of the four markers was indicative of benign tumour. Levels of CSF-1 did not correlate with the levels of any of the markers of collagen turnover. The concentration of PINP in ascites was about 50 times higher and in cyst fluid about eight times higher than that in the serum from patients with malignant tumour, whereas the respective ratios for ICTP were only 2.5 and 1.3. In such patients, the ratio of ascitic fluid to serum concentration was also about 80-fold higher for PIIINP and about 20-fold higher for PINP than for ICTP. The different distributions of PIIINP, PINP and ICTP suggests dominance of synthetic processes or retarted elimination of PIIINP and PINP in ovarian cancer. In advanced malignancies, the accumulation of PINP and PIIINP in abdominal space, possibly due to increased synthesis and/or failed resorption, may promote ascites formation. This study shows that both accelerated synthesis and breakdown of fibrillar collagens are characteristic of ovarian malignancy, and suggests that measurements of cyst fluid or ascitic fluid concentrations of collagen metabolites or CSF-1 could be used in the differential diagnosis of benign and malignant ovarian neoplasms.

AB - The synthesis and degradation of type I and type III interstitial collagens releases several antigenic metabolites, whose measurement allows the metabolism of connective tissue to be evaluated under a variety of different conditions. In this study we investigated the influence of benign and malignant ovarian neoplasms on the metabolism of these collagens. The study population comprised patients with benign (n = 53), borderline (n = 6) or malignant (n = 36) ovarian neoplasms. We quantified the serum, cyst fluid and peritoneal/ascitic fluid concentrations of the amino-terminal propeptide of type I (PINP) and III (PIIINP) procollagens, indicators of the synthesis of type I and III collagen, respectively and the cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), an indicator of type I collagen degradation. Macrophage colony-stimulating factor 1 (CSF-1) concentration was also assayed as its serum level is increased in ovarian cancer and CSF-1 may be involved in the regulation of collagen metabolism. The concentration of each antigen was significantly higher in patients with malignant tumour than with benign neoplasm in each comparison, except for ICTP in peritoneal fluid and for CSF-1 in cyst fluid. The high ascitic fluid concentration of PINP, PIIINP or CSF-1 correlated with malignancy, and the low cyst fluid concentration of any of the four markers was indicative of benign tumour. Levels of CSF-1 did not correlate with the levels of any of the markers of collagen turnover. The concentration of PINP in ascites was about 50 times higher and in cyst fluid about eight times higher than that in the serum from patients with malignant tumour, whereas the respective ratios for ICTP were only 2.5 and 1.3. In such patients, the ratio of ascitic fluid to serum concentration was also about 80-fold higher for PIIINP and about 20-fold higher for PINP than for ICTP. The different distributions of PIIINP, PINP and ICTP suggests dominance of synthetic processes or retarted elimination of PIIINP and PINP in ovarian cancer. In advanced malignancies, the accumulation of PINP and PIIINP in abdominal space, possibly due to increased synthesis and/or failed resorption, may promote ascites formation. This study shows that both accelerated synthesis and breakdown of fibrillar collagens are characteristic of ovarian malignancy, and suggests that measurements of cyst fluid or ascitic fluid concentrations of collagen metabolites or CSF-1 could be used in the differential diagnosis of benign and malignant ovarian neoplasms.

KW - Ascites formation

KW - Macrophage colony-stimulating factor 1

KW - Matrix reaction

KW - Tumour-associated marker

KW - Type I collagen

KW - Type III collagen

UR - http://www.scopus.com/inward/record.url?scp=0031802004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031802004&partnerID=8YFLogxK

M3 - Article

C2 - 9667653

AN - SCOPUS:0031802004

VL - 77

SP - 1825

EP - 1831

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 11

ER -