Synthesis and biological studies of new lipid-soluble cisplatin analogues entrapped in liposomes

Salaam Al-Baker, Roman Perez-Soler, Abdul R. Khokhar

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of highly lipophilic platinum(II) complexes of the type cis-[(RNH2)2PtX2] have been synthesized, where R = ethyl, propyl, isopropyl, butyl, cyclopropyl, cyclopentyl, or neopentyl and X = either long-chain carboxylate, such as decanoate (C10), laurate (C12), myristate (C14), heptadecanoate (C17), stearate (C18), nonadecanoate (C19), or 2,2,3,3-tetramethylcyclopropylcarboxylate, or branched-chain carboxylate, such as neopentanoate, neohexanoate, neoheptanoate, neononanoate, or neodecanoate. These complexes have been characterized by elemental analysis, IR, and 13C and 195Pt NMR spectroscopic techniques. The platinum complexes were entrapped in multilamellar vesicles composed of dimyristoyl phosphatidylcholine (DMPC) and dimyristoyl phosphatidylglycerol (DMPG) at a 7:3 molar ratio and tested for antitumor activity. The entrapment efficiency of liposomal platinum (L-Pt) complexes ranged from 60 to 100%. The percentage of T/C obtained after a single i.p. injection of the optimal dose of L-Pt complexes tested against L1210 leukemia ranged from 90 to 125%. These L-Pt preparations did not show significant antitumor activity in mice.

Original languageEnglish (US)
Pages (from-to)99-108
Number of pages10
JournalJournal of Inorganic Biochemistry
Volume47
Issue number2
DOIs
StatePublished - Aug 1 1992
Externally publishedYes

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Platinum
Liposomes
Cisplatin
Lipids
Laurates
Decanoates
Leukemia L1210
Stearates
Myristic Acid
Phosphatidylcholines
Nuclear magnetic resonance
Injections
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Synthesis and biological studies of new lipid-soluble cisplatin analogues entrapped in liposomes. / Al-Baker, Salaam; Perez-Soler, Roman; Khokhar, Abdul R.

In: Journal of Inorganic Biochemistry, Vol. 47, No. 2, 01.08.1992, p. 99-108.

Research output: Contribution to journalArticle

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