The synthesis of analogs of tetra‐l‐alanine containing 3‐fluoro‐l‐alanine selectively incorporated at each position is described. The standard procedures in the literature used to couple l‐alanine peptides together were often found to lead to undesired products, or elimination reactions when corresponding 3‐fluoro‐l‐alanine peptide analogs were used. Several modified procedures have thus been developed for the synthesis of fluorine‐substituted analogs. In addition, the pH‐dependence of 19F n.m.r. spectra of 3‐fluoro‐l‐alanine and the tetrapeptide analogs is presented.
|Original language||English (US)|
|Number of pages||7|
|Journal||International Journal of Peptide and Protein Research|
|Publication status||Published - Oct 1983|
- 19F n.m.r.
- peptide synthesis
ASJC Scopus subject areas