Synopsis of preterm birth genetic association studies: The preterm birth genetics knowledge base (PTBGene)

Siobhan M. Dolan, M. V. Hollegaard, M. Merialdi, A. P. Betran, T. Allen, Chaya B. Abelow, J. Nace, B. K. Lin, M. J. Khoury, J. P A Ioannidis, S. Bagade, X. Zheng, Robert A. Dubin, L. Bertram, D. R. Velez Edwards, R. Menon

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Aim: Our goal wasto produce a field synopsis of genetic associations with preterm birth and to set up a publicly available online database summarizing the data. Methods: We performed a systematic review and meta-analyses to identify genetic associations with preterm birth. We have set up a publicly available online database of genetic association data on preterm birth called PTBGene (http://ric.einstein.yu.edu/ptbgene/index.html) and report on a structured synopsis thereof as of December 1, 2008. Results: Data on 189 polymorphisms in 84 genes have been included and 36 meta-analyses have been performed. Five gene variants (4 in maternal DNA, one in newborn DNA) have shown nominally significant associations, but all have weak epidemiological credibility. Conclusion: After publishing this field synopsis, the PTBGene database will be regularly updated to keep track of the evolving evidence base of genetic factors in preterm birth with the goal of promoting knowledge sharing and multicenter collaboration among preterm birth research groups.

Original languageEnglish (US)
Pages (from-to)514-523
Number of pages10
JournalPublic Health Genomics
Volume13
Issue number7-8
DOIs
StatePublished - Dec 2010

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Knowledge Bases
Premature Birth
Genetic Association Studies
Meta-Analysis
Databases
Genetic Databases
DNA
Genes
Mothers
Research

Keywords

  • HuGE review
  • Meta-analysis
  • Prematurity
  • Preterm birth
  • Systematic review

ASJC Scopus subject areas

  • Genetics(clinical)
  • Public Health, Environmental and Occupational Health

Cite this

Synopsis of preterm birth genetic association studies : The preterm birth genetics knowledge base (PTBGene). / Dolan, Siobhan M.; Hollegaard, M. V.; Merialdi, M.; Betran, A. P.; Allen, T.; Abelow, Chaya B.; Nace, J.; Lin, B. K.; Khoury, M. J.; Ioannidis, J. P A; Bagade, S.; Zheng, X.; Dubin, Robert A.; Bertram, L.; Velez Edwards, D. R.; Menon, R.

In: Public Health Genomics, Vol. 13, No. 7-8, 12.2010, p. 514-523.

Research output: Contribution to journalArticle

Dolan, SM, Hollegaard, MV, Merialdi, M, Betran, AP, Allen, T, Abelow, CB, Nace, J, Lin, BK, Khoury, MJ, Ioannidis, JPA, Bagade, S, Zheng, X, Dubin, RA, Bertram, L, Velez Edwards, DR & Menon, R 2010, 'Synopsis of preterm birth genetic association studies: The preterm birth genetics knowledge base (PTBGene)', Public Health Genomics, vol. 13, no. 7-8, pp. 514-523. https://doi.org/10.1159/000294202
Dolan, Siobhan M. ; Hollegaard, M. V. ; Merialdi, M. ; Betran, A. P. ; Allen, T. ; Abelow, Chaya B. ; Nace, J. ; Lin, B. K. ; Khoury, M. J. ; Ioannidis, J. P A ; Bagade, S. ; Zheng, X. ; Dubin, Robert A. ; Bertram, L. ; Velez Edwards, D. R. ; Menon, R. / Synopsis of preterm birth genetic association studies : The preterm birth genetics knowledge base (PTBGene). In: Public Health Genomics. 2010 ; Vol. 13, No. 7-8. pp. 514-523.
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