Synergistic effect of nitrilotriacetate on iron mobilization by desferrioxamine in vivo

Simeon Pollack, s. Ruocco

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Removal of iron from biologically important ligands by desferrioxamine (DF), in vitro, is exceedingly slow because of a kinetic barrier. This kinetic barrier can be overcome by a variety of a small molecular weight anions, of which nitrilotriacetate (NTA) is a prototype. We explored the effect of NTA on DF iron mobilization in vivo. Iron mobilization was increased and the effect was synergistic.

Original languageEnglish (US)
Pages (from-to)1117-1118
Number of pages2
JournalBlood
Volume57
Issue number6
StatePublished - 1981

Fingerprint

Deferoxamine
Iron
Kinetics
Anions
Molecular Weight
Molecular weight
Ligands
ferric nitrilotriacetate

ASJC Scopus subject areas

  • Hematology

Cite this

Synergistic effect of nitrilotriacetate on iron mobilization by desferrioxamine in vivo. / Pollack, Simeon; Ruocco, s.

In: Blood, Vol. 57, No. 6, 1981, p. 1117-1118.

Research output: Contribution to journalArticle

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