Synergistic effect of nitrilotriacetate on iron mobilization by desferrioxamine in vivo

S. Pollack, s. Ruocco

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Removal of iron from biologically important ligands by desferrioxamine (DF), in vitro, is exceedingly slow because of a kinetic barrier. This kinetic barrier can be overcome by a variety of a small molecular weight anions, of which nitrilotriacetate (NTA) is a prototype. We explored the effect of NTA on DF iron mobilization in vivo. Iron mobilization was increased and the effect was synergistic.

Original languageEnglish (US)
Pages (from-to)1117-1118
Number of pages2
JournalBlood
Volume57
Issue number6
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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