Abstract
This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 88-91 |
| Number of pages | 4 |
| Journal | Acta neuropathologica |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 1990 |
| Externally published | Yes |
Keywords
- Calcineurin
- Huntington's disease
- Immunohistochemistry
- Striatum
- Synaptophysin
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology
- Cellular and Molecular Neuroscience