Synaptophysin expression in the striatum in Huntington's disease

S. Goto, A. Hirano

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalActa neuropathologica
Volume80
Issue number1
DOIs
StatePublished - May 1 1990

Keywords

  • Calcineurin
  • Huntington's disease
  • Immunohistochemistry
  • Striatum
  • Synaptophysin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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