Synaptic corelease of ATP and GABA in cultured spinal neurons

Young Hwan Jo, Rémy Schlichter

Research output: Contribution to journalArticle

279 Scopus citations


In the spinal dorsal horn (DH), transmission and modulation of peripheral nociceptive (pain-inducing) messages involve classical neurotransmitters and neuropeptides. We show that approximately half of DH neurons use ATP as a fast excitatory neurotransmitter acting at ionotropic P2X postsynaptic receptors. ATP was not codetected with glutamate but was coreleased with the inhibitory neurotransmitter GABA. Moreover, adenosine, probably generated by extracellular metabolism of ATP, finely tuned GABAergic inhibitory postsynaptic currents. Differential modulation of excitatory versus inhibitory components of this mixed cotransmission may help to explain changes in sensory message processing in the DH during mechanical hyperalgesia and neuropathic pain.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalNature Neuroscience
Issue number3
Publication statusPublished - Mar 1 1999
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

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