Symptom domains in autism and related conditions: Evidence for familiality

Jeremy M. Silverman, Christopher J. Smith, James Schmeidler, Eric Hollander, Brian A. Lawlor, Michael Fitzgerald, Joseph D. Buxbaum, Katherine Delaney, Patricia Galvin, Daniel H. Geschwind, Maya Bucan, W. Ted Brown, Edwin H. Cook, T. Conrad Gilliam, David A. Greenberg, David H. Ledbetter, Bruce Miller, Stanley F. Nelson, Jonathon Pevsner, Jerome I. RotterGerard D. Schellenberg, Carol A. Sprouse, Rudolph E. Tanzi, Kirk C. Wilhelmsen

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Heterogeneity in autism impairs efforts to localize and identify the genes underlying this disorder. As autism comprises severe but variable deficits and traits in three symptom domains (social interaction, communication, and repetitive behaviors) and shows variability in the presence and emergence of useful phrase speech, different genetic factors may be associated with each. The affected cases (n=457) in multiply affected siblingships (n=212), including a proband with autism and one or more siblings with either autism or marked deficits in autism symptom domains, were assessed using the Autism Diagnostic Interview, Revised. Symptom domain scores and language features were examined to determine their similarity within siblingships. The variance within siblingships was reduced for the repetitive behavior domain and for delays in and the presence of useful phrase speech. These features and the nonverbal communication subdomain provided evidence of familiality when we considered only the diagnosis of autism to define multiply affected siblingships (cases: n=289; siblingships: n=136). In addition, the same familial features identified also appeared familial for those with autism-related conditions. Finally, the level of severity of almost all of the familial features varied within multiplex siblingships independently. The features identified as familial replicate the combined set suggested in earlier, smaller studies. Furthermore, the familiality of these features extend to related conditions of milder severity than autism and appear to be independent. Making distinctions among families by the severity of these features may be useful for identifying more genetically homogeneous subgroups in studies targeted at genes for specific autism-related symptom domains.

Original languageEnglish (US)
Pages (from-to)64-73
Number of pages10
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume114
Issue number1
DOIs
StatePublished - Jan 8 2002
Externally publishedYes

Keywords

  • Affected sibling pairs
  • Asperger disorder
  • Autism spectrum
  • Broader affected phenotype
  • Genetics
  • Heterogeneity
  • Multiplex siblingships

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Symptom domains in autism and related conditions: Evidence for familiality'. Together they form a unique fingerprint.

  • Cite this

    Silverman, J. M., Smith, C. J., Schmeidler, J., Hollander, E., Lawlor, B. A., Fitzgerald, M., Buxbaum, J. D., Delaney, K., Galvin, P., Geschwind, D. H., Bucan, M., Brown, W. T., Cook, E. H., Gilliam, T. C., Greenberg, D. A., Ledbetter, D. H., Miller, B., Nelson, S. F., Pevsner, J., ... Wilhelmsen, K. C. (2002). Symptom domains in autism and related conditions: Evidence for familiality. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 114(1), 64-73. https://doi.org/10.1002/ajmg.10048