Symposium: New data for noise standards: III. Organ culture of the mammalian inner ear: A tool to study inner ear deafness

Thomas Van De Water, Robert J. Ruben

Research output: Contribution to journalArticle

16 Scopus citations


Twelfth gestation day kreisler otocysts were explanted into an organ culture system and allowed to develop for nine days. The homozygotic (kr/kr) kreisler otocysts showed significant developmental differences when compared to the development that occurred in the organ culture specimens of the otocysts of its heterozygotic (+ /kr) litter mates. The differences in development observed in vitro were the same major developmental differences that had been observed in vivo. The phenotypic expression of the kreisler genome has expressed itself in vitro in the homozygotic kreisler otocyst.

Original languageEnglish (US)
Pages (from-to)738-749
Number of pages12
Issue number5
Publication statusPublished - May 1974


ASJC Scopus subject areas

  • Otorhinolaryngology

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