Sympathetic nervous system signaling in heart failure and cardiac aging

Gaetano Santulli

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Heart failure represents the leading cause of death, especially among the elderly. Despite the development of numerous therapeutic strategies, heart failure prevalence is still increasing. Ergo, exploring the molecular mechanisms underlying aging-related heart failure seems to be of particular relevance. Intriguingly, the fields of cardiovascular disease and aging, which have remained largely separate hitherto, seem to have a common point in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disease. This chapter will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiac aging.

Original languageEnglish (US)
Title of host publicationPathophysiology and Pharmacotherapy of Cardiovascular Disease
PublisherSpringer International Publishing
Pages83-105
Number of pages23
ISBN (Electronic)9783319159614
ISBN (Print)9783319159607
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Keywords

  • Adrenergic receptors
  • Aging
  • Arrhythmias
  • Cardiomyocytes
  • Endothelium
  • GRKs
  • Heart failure
  • Hypertension
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Santulli, G. (2015). Sympathetic nervous system signaling in heart failure and cardiac aging. In Pathophysiology and Pharmacotherapy of Cardiovascular Disease (pp. 83-105). Springer International Publishing. https://doi.org/10.1007/978-3-319-15961-4_5