Swimming into the future of drug discovery

In vivo chemical screens in zebrafish

Teresa V. Bowman, Leonard I. Zon

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalACS Chemical Biology
Volume5
Issue number2
DOIs
StatePublished - Feb 19 2010
Externally publishedYes

Fingerprint

Zebrafish
Drug Discovery
Screening
Biological Phenomena
Structure-Activity Relationship
Pharmaceutical Preparations
Lead compounds
Bioactivity
Toxicity
Swimming

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Swimming into the future of drug discovery : In vivo chemical screens in zebrafish. / Bowman, Teresa V.; Zon, Leonard I.

In: ACS Chemical Biology, Vol. 5, No. 2, 19.02.2010, p. 159-161.

Research output: Contribution to journalArticle

@article{88e43d8f2b1d457298929bb252d1d875,
title = "Swimming into the future of drug discovery: In vivo chemical screens in zebrafish",
abstract = "In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.",
author = "Bowman, {Teresa V.} and Zon, {Leonard I.}",
year = "2010",
month = "2",
day = "19",
doi = "10.1021/cb100029t",
language = "English (US)",
volume = "5",
pages = "159--161",
journal = "ACS Chemical Biology",
issn = "1554-8929",
publisher = "American Chemical Society",
number = "2",

}

TY - JOUR

T1 - Swimming into the future of drug discovery

T2 - In vivo chemical screens in zebrafish

AU - Bowman, Teresa V.

AU - Zon, Leonard I.

PY - 2010/2/19

Y1 - 2010/2/19

N2 - In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.

AB - In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.

UR - http://www.scopus.com/inward/record.url?scp=77449155155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77449155155&partnerID=8YFLogxK

U2 - 10.1021/cb100029t

DO - 10.1021/cb100029t

M3 - Article

VL - 5

SP - 159

EP - 161

JO - ACS Chemical Biology

JF - ACS Chemical Biology

SN - 1554-8929

IS - 2

ER -