Swimming into the future of drug discovery: In vivo chemical screens in zebrafish

Teresa V. Bowman, Leonard I. Zon

Research output: Contribution to journalShort survey

78 Scopus citations

Abstract

In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalACS Chemical Biology
Volume5
Issue number2
DOIs
StatePublished - Feb 19 2010
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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