Sustained release nitric oxide releasing nanoparticles: Characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites

Adam J. Friedman, George Han, Mahantesh S. Navati, Manju Chacko, Leslie Gunther, Alan Alfieri, Joel M. Friedman

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

A new platform using biocompatible materials is presented for generating powders comprised of nanoparticles that release therapeutic levels of nitric oxide (NO) in a controlled and sustained manner. The capacity of these particles to retain and gradually release NO arises from their having combined features of both glassy matrices and hydrogels. This feature allows both for the generation of NO through the thermal reduction of added nitrite by glucose and for the retention of the generated NO within the dry particles. Exposure of these robust biocompatible nanoparticles to moisture initiates the sustained release of the trapped NO over extended time periods as determined both fluorimetrically and amperometrically. The slow sustained release is in contrast to the much faster release pattern associated with the hydration-initialed NO release in powders derived from glassy matrices. These glasses are prepared using trehalose and sucrose doped with either glucose or tagatose as the source of thermal electrons needed to convert nitrite to gNO. Significantly, the release profiles for the NO in the hydrogel/glass composite materials are found to be an easily tuned parameter that is modulated through the specific additives used in preparing the hydrogel/glass composites. The presented data raise the prospect that these new NO releasing nanoparticles can be easily formulated for use under a wide range of therapeutic circumstances.

Original languageEnglish (US)
Pages (from-to)12-20
Number of pages9
JournalNitric Oxide - Biology and Chemistry
Volume19
Issue number1
DOIs
StatePublished - Aug 1 2008

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Keywords

  • Chitosan
  • Glucose
  • Hydrogel
  • Nanotechnology
  • Nitric oxide
  • Nitrite
  • PEG
  • Platform technology
  • Sucrose
  • Sustained release
  • Tagatose
  • Trehalose

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cancer Research

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