Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021

Mark W. Tenforde; Wesley H. Self; Eric A. Naioti; Adit A. Ginde; David J. Douin; Samantha M. Olson; H. Keipp Talbot; Jonathan D. Casey; Nicholas M. Mohr; Anne Zepeski; Manjusha Gaglani; Tresa McNeal; Shekhar Ghamande; Nathan I. Shapiro; Kevin W. Gibbs; D. Clark Files; David N. Hager; Arber Shehu; Matthew E. Prekker; Heidi L. Erickson; Michelle N. Gong; Amira Mohamed; Daniel J. Henning; Jay S. Steingrub; Ithan D. Peltan; Samuel M. Brown; Emily T. Martin; Arnold S. Monto; Akram Khan; Catherine L. Hough; Laurence W. Busse; Caitlin C. ten Lohuis; Abhijit Duggal; Jennifer G. Wilson; Alexandra June Gordon; Nida Qadir; Steven Y. Chang; Christopher Mallow; Carolina Rivas; Hilary M. Babcock; Jennie H. Kwon; Matthew C. Exline; Natasha Halasa; James D. Chappell; Adam S. Lauring; Carlos G. Grijalva; Todd W. Rice; Ian D. Jones; William B. Stubblefield; Adrienne Baughman; Kelsey N. Womack; Christopher J. Lindsell; Kimberly W. Hart; Yuwei Zhu; Meagan Stephenson; Stephanie J. Schrag; Miwako Kobayashi; Jennifer R. Verani; Manish M. Patel

doi:10.15585/MMWR.MM7034E2

Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021

Mark W. Tenforde, Wesley H. Self, Eric A. Naioti, Adit A. Ginde, David J. Douin, Samantha M. Olson, H. Keipp Talbot, Jonathan D. Casey, Nicholas M. Mohr, Anne Zepeski, Manjusha Gaglani, Tresa McNeal, Shekhar Ghamande, Nathan I. Shapiro, Kevin W. Gibbs, D. Clark Files, David N. Hager, Arber Shehu, Matthew E. Prekker, Heidi L. EricksonMichelle N. Gong, Amira Mohamed, Daniel J. Henning, Jay S. Steingrub, Ithan D. Peltan, Samuel M. Brown, Emily T. Martin, Arnold S. Monto, Akram Khan, Catherine L. Hough, Laurence W. Busse, Caitlin C. ten Lohuis, Abhijit Duggal, Jennifer G. Wilson, Alexandra June Gordon, Nida Qadir, Steven Y. Chang, Christopher Mallow, Carolina Rivas, Hilary M. Babcock, Jennie H. Kwon, Matthew C. Exline, Natasha Halasa, James D. Chappell, Adam S. Lauring, Carlos G. Grijalva, Todd W. Rice, Ian D. Jones, William B. Stubblefield, Adrienne Baughman, Kelsey N. Womack, Christopher J. Lindsell, Kimberly W. Hart, Yuwei Zhu, Meagan Stephenson, Stephanie J. Schrag, Miwako Kobayashi, Jennifer R. Verani, Manish M. Patel

Research output: Contribution to journal › Review article › peer-review

67 Scopus citations

Abstract

In a multistate network that enrolled adults hospitalized during March-July 2021, effectiveness of 2 doses of mRNA vaccine against COVID-19-associated hospitalization was sustained over a follow-up period of 24 weeks (approximately 6 months). These findings of sustained VE were consistent among subgroups at highest risk for severe outcomes from COVID-19, including older adults, adults with three or more chronic medical conditions, and those with immunocompromising conditions. Overall VE in adults with immunocompromising conditions was lower than that in those without immunocompromising conditions but was sustained over time in both populations.

Original language	English (US)
Pages (from-to)	1156-1162
Number of pages	7
Journal	Morbidity and Mortality Weekly Report
Volume	70
Issue number	34
DOIs	https://doi.org/10.15585/MMWR.MM7034E2
State	Published - Aug 2021
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Health(social science)
Health, Toxicology and Mutagenesis
Health Information Management

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10.15585/MMWR.MM7034E2

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Tenforde, M. W., Self, W. H., Naioti, E. A., Ginde, A. A., Douin, D. J., Olson, S. M., Talbot, H. K., Casey, J. D., Mohr, N. M., Zepeski, A., Gaglani, M., McNeal, T., Ghamande, S., Shapiro, N. I., Gibbs, K. W., Files, D. C., Hager, D. N., Shehu, A., Prekker, M. E., ... Patel, M. M. (2021). Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021. Morbidity and Mortality Weekly Report, 70(34), 1156-1162. https://doi.org/10.15585/MMWR.MM7034E2

Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021. / Tenforde, Mark W.; Self, Wesley H.; Naioti, Eric A.; Ginde, Adit A.; Douin, David J.; Olson, Samantha M.; Talbot, H. Keipp; Casey, Jonathan D.; Mohr, Nicholas M.; Zepeski, Anne; Gaglani, Manjusha; McNeal, Tresa; Ghamande, Shekhar; Shapiro, Nathan I.; Gibbs, Kevin W.; Files, D. Clark; Hager, David N.; Shehu, Arber; Prekker, Matthew E.; Erickson, Heidi L.; Gong, Michelle N.; Mohamed, Amira; Henning, Daniel J.; Steingrub, Jay S.; Peltan, Ithan D.; Brown, Samuel M.; Martin, Emily T.; Monto, Arnold S.; Khan, Akram; Hough, Catherine L.; Busse, Laurence W.; ten Lohuis, Caitlin C.; Duggal, Abhijit; Wilson, Jennifer G.; Gordon, Alexandra June; Qadir, Nida; Chang, Steven Y.; Mallow, Christopher; Rivas, Carolina; Babcock, Hilary M.; Kwon, Jennie H.; Exline, Matthew C.; Halasa, Natasha; Chappell, James D.; Lauring, Adam S.; Grijalva, Carlos G.; Rice, Todd W.; Jones, Ian D.; Stubblefield, William B.; Baughman, Adrienne; Womack, Kelsey N.; Lindsell, Christopher J.; Hart, Kimberly W.; Zhu, Yuwei; Stephenson, Meagan; Schrag, Stephanie J.; Kobayashi, Miwako; Verani, Jennifer R.; Patel, Manish M.

In: Morbidity and Mortality Weekly Report, Vol. 70, No. 34, 08.2021, p. 1156-1162.

Research output: Contribution to journal › Review article › peer-review

Tenforde, MW, Self, WH, Naioti, EA, Ginde, AA, Douin, DJ, Olson, SM, Talbot, HK, Casey, JD, Mohr, NM, Zepeski, A, Gaglani, M, McNeal, T, Ghamande, S, Shapiro, NI, Gibbs, KW, Files, DC, Hager, DN, Shehu, A, Prekker, ME, Erickson, HL, Gong, MN , Mohamed, A, Henning, DJ, Steingrub, JS, Peltan, ID, Brown, SM, Martin, ET, Monto, AS, Khan, A, Hough, CL, Busse, LW, ten Lohuis, CC, Duggal, A, Wilson, JG, Gordon, AJ, Qadir, N, Chang, SY, Mallow, C, Rivas, C, Babcock, HM, Kwon, JH, Exline, MC, Halasa, N, Chappell, JD, Lauring, AS, Grijalva, CG, Rice, TW, Jones, ID, Stubblefield, WB, Baughman, A, Womack, KN, Lindsell, CJ, Hart, KW, Zhu, Y, Stephenson, M, Schrag, SJ, Kobayashi, M, Verani, JR & Patel, MM 2021, 'Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021', Morbidity and Mortality Weekly Report, vol. 70, no. 34, pp. 1156-1162. https://doi.org/10.15585/MMWR.MM7034E2

Tenforde, Mark W. ; Self, Wesley H. ; Naioti, Eric A. ; Ginde, Adit A. ; Douin, David J. ; Olson, Samantha M. ; Talbot, H. Keipp ; Casey, Jonathan D. ; Mohr, Nicholas M. ; Zepeski, Anne ; Gaglani, Manjusha ; McNeal, Tresa ; Ghamande, Shekhar ; Shapiro, Nathan I. ; Gibbs, Kevin W. ; Files, D. Clark ; Hager, David N. ; Shehu, Arber ; Prekker, Matthew E. ; Erickson, Heidi L. ; Gong, Michelle N. ; Mohamed, Amira ; Henning, Daniel J. ; Steingrub, Jay S. ; Peltan, Ithan D. ; Brown, Samuel M. ; Martin, Emily T. ; Monto, Arnold S. ; Khan, Akram ; Hough, Catherine L. ; Busse, Laurence W. ; ten Lohuis, Caitlin C. ; Duggal, Abhijit ; Wilson, Jennifer G. ; Gordon, Alexandra June ; Qadir, Nida ; Chang, Steven Y. ; Mallow, Christopher ; Rivas, Carolina ; Babcock, Hilary M. ; Kwon, Jennie H. ; Exline, Matthew C. ; Halasa, Natasha ; Chappell, James D. ; Lauring, Adam S. ; Grijalva, Carlos G. ; Rice, Todd W. ; Jones, Ian D. ; Stubblefield, William B. ; Baughman, Adrienne ; Womack, Kelsey N. ; Lindsell, Christopher J. ; Hart, Kimberly W. ; Zhu, Yuwei ; Stephenson, Meagan ; Schrag, Stephanie J. ; Kobayashi, Miwako ; Verani, Jennifer R. ; Patel, Manish M. / Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021. In: Morbidity and Mortality Weekly Report. 2021 ; Vol. 70, No. 34. pp. 1156-1162.

@article{da2f547aa14a4bd3a97f885d92dc59be,

title = "Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021",

abstract = "In a multistate network that enrolled adults hospitalized during March-July 2021, effectiveness of 2 doses of mRNA vaccine against COVID-19-associated hospitalization was sustained over a follow-up period of 24 weeks (approximately 6 months). These findings of sustained VE were consistent among subgroups at highest risk for severe outcomes from COVID-19, including older adults, adults with three or more chronic medical conditions, and those with immunocompromising conditions. Overall VE in adults with immunocompromising conditions was lower than that in those without immunocompromising conditions but was sustained over time in both populations.",

author = "Tenforde, {Mark W.} and Self, {Wesley H.} and Naioti, {Eric A.} and Ginde, {Adit A.} and Douin, {David J.} and Olson, {Samantha M.} and Talbot, {H. Keipp} and Casey, {Jonathan D.} and Mohr, {Nicholas M.} and Anne Zepeski and Manjusha Gaglani and Tresa McNeal and Shekhar Ghamande and Shapiro, {Nathan I.} and Gibbs, {Kevin W.} and Files, {D. Clark} and Hager, {David N.} and Arber Shehu and Prekker, {Matthew E.} and Erickson, {Heidi L.} and Gong, {Michelle N.} and Amira Mohamed and Henning, {Daniel J.} and Steingrub, {Jay S.} and Peltan, {Ithan D.} and Brown, {Samuel M.} and Martin, {Emily T.} and Monto, {Arnold S.} and Akram Khan and Hough, {Catherine L.} and Busse, {Laurence W.} and {ten Lohuis}, {Caitlin C.} and Abhijit Duggal and Wilson, {Jennifer G.} and Gordon, {Alexandra June} and Nida Qadir and Chang, {Steven Y.} and Christopher Mallow and Carolina Rivas and Babcock, {Hilary M.} and Kwon, {Jennie H.} and Exline, {Matthew C.} and Natasha Halasa and Chappell, {James D.} and Lauring, {Adam S.} and Grijalva, {Carlos G.} and Rice, {Todd W.} and Jones, {Ian D.} and Stubblefield, {William B.} and Adrienne Baughman and Womack, {Kelsey N.} and Lindsell, {Christopher J.} and Hart, {Kimberly W.} and Yuwei Zhu and Meagan Stephenson and Schrag, {Stephanie J.} and Miwako Kobayashi and Verani, {Jennifer R.} and Patel, {Manish M.}",

note = "Funding Information: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Samuel M. Brown reports personal fees from Hamilton, institutional fees from Faron Pharmaceuticals and Sedana, grants from Janssen, the National Institutes of Health (NIH), and the Department of Defense (DoD), book royalties from Oxford University and Brigham Young University, outside the submitted work. Jonathan D. Casey reports grants from NIH, outside the submitted work. Steven Y. Chang was a speaker for La Jolla Pharmaceuticals in 2018 and consulted for PureTech Health in 2020. James D. Chappell reports grants from NIH during the conduct of the study. Matthew C. Exline reports support from Abbott Labs for sponsored talks, outside the submitted work. D. Clark Files reports personal consultant fees from Cytovale and is a data and safety monitoring board (DSMB) member from Medpace, outside the submitted work. Adit A. Ginde reports grants from NIH, DoD, AbbVie, and Faron Pharmaceuticals, outside the submitted work. Michelle N. Gong reports grants from NIH and the Agency for Healthcare Research and Quality (AHRQ), DSMB membership fees from Regeneron, and personal fees from Philips Healthcare, outside the submitted work. Carlos G. Grijalva reports consultancy fees from Pfizer, Merck, and Sanofi-Pasteur; grants from Campbell Alliance/Syneos Health, NIH, the Food and Drug Administration, AHQR, and Sanofi, outside the submitted work. David N. Hager reports salary support from Incyte Corporation, the Marcus Foundation, and EMPACT Precision Medicine via Vanderbilt University Medical Center, outside the submitted work. Natasha Halasa reports grants and nonfinancial support from Sanofi, and Quidel outside the submitted work. Daniel J. Henning reports personal consultant fees from Cytovale and Opticyte. Akram Khan reports grants from United Therapeutics, Johnson & Johnson, 4D Medical, Lung LLC, and Reata Pharmaceuticals, outside the submitted work. Adam S. Lauring reports personal fees from Sanofi and Roche, outside the submitted work. Christopher J. Lindsell reports grants from NIH, DoD, and the Marcus Foundation; contract fees from bioMerieux, Endpoint LLC, and Entegrion Inc, outside the submitted work and has a patent for risk stratification in sepsis and septic shock issued. Emily T. Martin reports personal fees from Pfizer and grants from Merck, outside the submitted work. Arnold S. Monto reports consulting fees from Sanofi-Pasteur and Seqirus outside the submitted work. Ithan D. Peltan reports grants from NIH and Janssen Pharmaceuticals and institutional support from Asahi Kasei Pharma and Regeneron, outside the submitted work. Todd W. Rice reports personal fees from Cumberland Pharmaceuticals, Inc. and personal fees from Avisa Pharma, LLC and Sanofi, outside the submitted work. Wesley H. Self reports consulting fees from Aeprio Pharmaceuticals and Merck outside the submitted work. No other potential conflicts of interest were disclosed. Publisher Copyright: {\textcopyright} 2021 Department of Health and Human Services. All rights reserved.",

year = "2021",

month = aug,

doi = "10.15585/MMWR.MM7034E2",

language = "English (US)",

volume = "70",

pages = "1156--1162",

journal = "Morbidity and Mortality Weekly Report",

issn = "0149-2195",

publisher = "Department of Health and Human Services",

number = "34",

}

TY - JOUR

T1 - Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021

AU - Tenforde, Mark W.

AU - Self, Wesley H.

AU - Naioti, Eric A.

AU - Ginde, Adit A.

AU - Douin, David J.

AU - Olson, Samantha M.

AU - Talbot, H. Keipp

AU - Casey, Jonathan D.

AU - Mohr, Nicholas M.

AU - Zepeski, Anne

AU - Gaglani, Manjusha

AU - McNeal, Tresa

AU - Ghamande, Shekhar

AU - Shapiro, Nathan I.

AU - Gibbs, Kevin W.

AU - Files, D. Clark

AU - Hager, David N.

AU - Shehu, Arber

AU - Prekker, Matthew E.

AU - Erickson, Heidi L.

AU - Gong, Michelle N.

AU - Mohamed, Amira

AU - Henning, Daniel J.

AU - Steingrub, Jay S.

AU - Peltan, Ithan D.

AU - Brown, Samuel M.

AU - Martin, Emily T.

AU - Monto, Arnold S.

AU - Khan, Akram

AU - Hough, Catherine L.

AU - Busse, Laurence W.

AU - ten Lohuis, Caitlin C.

AU - Duggal, Abhijit

AU - Wilson, Jennifer G.

AU - Gordon, Alexandra June

AU - Qadir, Nida

AU - Chang, Steven Y.

AU - Mallow, Christopher

AU - Rivas, Carolina

AU - Babcock, Hilary M.

AU - Kwon, Jennie H.

AU - Exline, Matthew C.

AU - Halasa, Natasha

AU - Chappell, James D.

AU - Lauring, Adam S.

AU - Grijalva, Carlos G.

AU - Rice, Todd W.

AU - Jones, Ian D.

AU - Stubblefield, William B.

AU - Baughman, Adrienne

AU - Womack, Kelsey N.

AU - Lindsell, Christopher J.

AU - Hart, Kimberly W.

AU - Zhu, Yuwei

AU - Stephenson, Meagan

AU - Schrag, Stephanie J.

AU - Kobayashi, Miwako

AU - Verani, Jennifer R.

AU - Patel, Manish M.

N1 - Funding Information: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Samuel M. Brown reports personal fees from Hamilton, institutional fees from Faron Pharmaceuticals and Sedana, grants from Janssen, the National Institutes of Health (NIH), and the Department of Defense (DoD), book royalties from Oxford University and Brigham Young University, outside the submitted work. Jonathan D. Casey reports grants from NIH, outside the submitted work. Steven Y. Chang was a speaker for La Jolla Pharmaceuticals in 2018 and consulted for PureTech Health in 2020. James D. Chappell reports grants from NIH during the conduct of the study. Matthew C. Exline reports support from Abbott Labs for sponsored talks, outside the submitted work. D. Clark Files reports personal consultant fees from Cytovale and is a data and safety monitoring board (DSMB) member from Medpace, outside the submitted work. Adit A. Ginde reports grants from NIH, DoD, AbbVie, and Faron Pharmaceuticals, outside the submitted work. Michelle N. Gong reports grants from NIH and the Agency for Healthcare Research and Quality (AHRQ), DSMB membership fees from Regeneron, and personal fees from Philips Healthcare, outside the submitted work. Carlos G. Grijalva reports consultancy fees from Pfizer, Merck, and Sanofi-Pasteur; grants from Campbell Alliance/Syneos Health, NIH, the Food and Drug Administration, AHQR, and Sanofi, outside the submitted work. David N. Hager reports salary support from Incyte Corporation, the Marcus Foundation, and EMPACT Precision Medicine via Vanderbilt University Medical Center, outside the submitted work. Natasha Halasa reports grants and nonfinancial support from Sanofi, and Quidel outside the submitted work. Daniel J. Henning reports personal consultant fees from Cytovale and Opticyte. Akram Khan reports grants from United Therapeutics, Johnson & Johnson, 4D Medical, Lung LLC, and Reata Pharmaceuticals, outside the submitted work. Adam S. Lauring reports personal fees from Sanofi and Roche, outside the submitted work. Christopher J. Lindsell reports grants from NIH, DoD, and the Marcus Foundation; contract fees from bioMerieux, Endpoint LLC, and Entegrion Inc, outside the submitted work and has a patent for risk stratification in sepsis and septic shock issued. Emily T. Martin reports personal fees from Pfizer and grants from Merck, outside the submitted work. Arnold S. Monto reports consulting fees from Sanofi-Pasteur and Seqirus outside the submitted work. Ithan D. Peltan reports grants from NIH and Janssen Pharmaceuticals and institutional support from Asahi Kasei Pharma and Regeneron, outside the submitted work. Todd W. Rice reports personal fees from Cumberland Pharmaceuticals, Inc. and personal fees from Avisa Pharma, LLC and Sanofi, outside the submitted work. Wesley H. Self reports consulting fees from Aeprio Pharmaceuticals and Merck outside the submitted work. No other potential conflicts of interest were disclosed. Publisher Copyright: © 2021 Department of Health and Human Services. All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - In a multistate network that enrolled adults hospitalized during March-July 2021, effectiveness of 2 doses of mRNA vaccine against COVID-19-associated hospitalization was sustained over a follow-up period of 24 weeks (approximately 6 months). These findings of sustained VE were consistent among subgroups at highest risk for severe outcomes from COVID-19, including older adults, adults with three or more chronic medical conditions, and those with immunocompromising conditions. Overall VE in adults with immunocompromising conditions was lower than that in those without immunocompromising conditions but was sustained over time in both populations.

AB - In a multistate network that enrolled adults hospitalized during March-July 2021, effectiveness of 2 doses of mRNA vaccine against COVID-19-associated hospitalization was sustained over a follow-up period of 24 weeks (approximately 6 months). These findings of sustained VE were consistent among subgroups at highest risk for severe outcomes from COVID-19, including older adults, adults with three or more chronic medical conditions, and those with immunocompromising conditions. Overall VE in adults with immunocompromising conditions was lower than that in those without immunocompromising conditions but was sustained over time in both populations.

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U2 - 10.15585/MMWR.MM7034E2

DO - 10.15585/MMWR.MM7034E2

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AN - SCOPUS:85114093646

VL - 70

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JO - Morbidity and Mortality Weekly Report

JF - Morbidity and Mortality Weekly Report

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ER -

Sustained effectiveness of pfizer-biontech and moderna vaccines against covid-19 associated hospitalizations among adults - united states, march-july 2021

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