Surviving severe acute respiratory distress syndrome: Utility of open-lung biopsy and large doses of dexamethasone

Kedar S. Deshpande, David W. Appel, Margarita T. Camacho, Kathryn E. Tanaka, Vladimir Kvetan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The etiology of acute respiratory distress syndrome is wide and mortality is extremely high. We describe a patient dying from severe acute respiratory distress syndrome who had a tremendous recovery after receiving dexamethasone (1 g daily). This patient required positive end-expiratory pressure (up to 18 mm/Hg) and fractional inspiratory oxygen (up to 100%). Thirty-six hours after the large dose of corticosteroids, the respiratory mechanics and oxygenation were acceptable for extubation. Acute respiratory distress syndrome was proven and other etiologies of respiratory failure were ruled out by a bedside open-lung biopsy. The biopsy proven acute respiratory distress syndrome dramatically resolved with this salvage therapy. High-dose usage of corticosteroids for acute respiratory distress syndrome has tremendous potential.

Original languageEnglish (US)
Pages (from-to)713-715
Number of pages3
JournalAnnals of Thoracic Surgery
Volume79
Issue number2
DOIs
StatePublished - Feb 1 2005

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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