Surviving severe acute respiratory distress syndrome

Utility of open-lung biopsy and large doses of dexamethasone

Kedar S. Deshpande, David W. Appel, Margarita T. Camacho, Kathryn E. Tanaka, Vladimir Kvetan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The etiology of acute respiratory distress syndrome is wide and mortality is extremely high. We describe a patient dying from severe acute respiratory distress syndrome who had a tremendous recovery after receiving dexamethasone (1 g daily). This patient required positive end-expiratory pressure (up to 18 mm/Hg) and fractional inspiratory oxygen (up to 100%). Thirty-six hours after the large dose of corticosteroids, the respiratory mechanics and oxygenation were acceptable for extubation. Acute respiratory distress syndrome was proven and other etiologies of respiratory failure were ruled out by a bedside open-lung biopsy. The biopsy proven acute respiratory distress syndrome dramatically resolved with this salvage therapy. High-dose usage of corticosteroids for acute respiratory distress syndrome has tremendous potential.

Original languageEnglish (US)
Pages (from-to)713-715
Number of pages3
JournalAnnals of Thoracic Surgery
Volume79
Issue number2
DOIs
StatePublished - Feb 2005

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Severe Acute Respiratory Syndrome
Adult Respiratory Distress Syndrome
Dexamethasone
Biopsy
Lung
Adrenal Cortex Hormones
Respiratory Mechanics
Salvage Therapy
Positive-Pressure Respiration
Respiratory Insufficiency
Oxygen
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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Surviving severe acute respiratory distress syndrome : Utility of open-lung biopsy and large doses of dexamethasone. / Deshpande, Kedar S.; Appel, David W.; Camacho, Margarita T.; Tanaka, Kathryn E.; Kvetan, Vladimir.

In: Annals of Thoracic Surgery, Vol. 79, No. 2, 02.2005, p. 713-715.

Research output: Contribution to journalArticle

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