Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

Suzanne M. Hingley-Wilson; Vasan K. Sambandamurthy; William R. Jacobs

doi:10.1038/ni981

Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

Suzanne M. Hingley-Wilson, Vasan K. Sambandamurthy, William R. Jacobs

Microbiology & Immunology

Research output: Contribution to journal › Review article › peer-review

164 Scopus citations

Abstract

Studying defined mutants of Mycobacterium tuberculosis in the mouse model of infection has led to the discovery of attenuated mutants that fall into several phenotypic classes. These mutants are categorized by their growth characteristics compared with those of wild-type M. tuberculosis, and include severe growth in vivo mutants, growth in vivo mutants, persistence mutants, pathology mutants and dissemination mutants. Here, examples of each of these mutant phenotypes are described and classified accordingly. Defining the importance of mycobacterial gene products responsible for in vivo growth, persistence and the induction of immunopathology will lead to a greater understanding of the host-pathogen interaction and potentially to new antimycobacterial treatment options.

Original language	English (US)
Pages (from-to)	949-955
Number of pages	7
Journal	Nature Immunology
Volume	4
Issue number	10
DOIs	https://doi.org/10.1038/ni981
State	Published - Oct 1 2003

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ni981

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abstract = "Studying defined mutants of Mycobacterium tuberculosis in the mouse model of infection has led to the discovery of attenuated mutants that fall into several phenotypic classes. These mutants are categorized by their growth characteristics compared with those of wild-type M. tuberculosis, and include severe growth in vivo mutants, growth in vivo mutants, persistence mutants, pathology mutants and dissemination mutants. Here, examples of each of these mutant phenotypes are described and classified accordingly. Defining the importance of mycobacterial gene products responsible for in vivo growth, persistence and the induction of immunopathology will lead to a greater understanding of the host-pathogen interaction and potentially to new antimycobacterial treatment options.",

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AB - Studying defined mutants of Mycobacterium tuberculosis in the mouse model of infection has led to the discovery of attenuated mutants that fall into several phenotypic classes. These mutants are categorized by their growth characteristics compared with those of wild-type M. tuberculosis, and include severe growth in vivo mutants, growth in vivo mutants, persistence mutants, pathology mutants and dissemination mutants. Here, examples of each of these mutant phenotypes are described and classified accordingly. Defining the importance of mycobacterial gene products responsible for in vivo growth, persistence and the induction of immunopathology will lead to a greater understanding of the host-pathogen interaction and potentially to new antimycobacterial treatment options.

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Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

Abstract

ASJC Scopus subject areas

UN SDGs

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