Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

Suzanne M. Hingley-Wilson, Vasan K. Sambandamurthy, William R. Jacobs

Research output: Contribution to journalReview article

142 Scopus citations

Abstract

Studying defined mutants of Mycobacterium tuberculosis in the mouse model of infection has led to the discovery of attenuated mutants that fall into several phenotypic classes. These mutants are categorized by their growth characteristics compared with those of wild-type M. tuberculosis, and include severe growth in vivo mutants, growth in vivo mutants, persistence mutants, pathology mutants and dissemination mutants. Here, examples of each of these mutant phenotypes are described and classified accordingly. Defining the importance of mycobacterial gene products responsible for in vivo growth, persistence and the induction of immunopathology will lead to a greater understanding of the host-pathogen interaction and potentially to new antimycobacterial treatment options.

Original languageEnglish (US)
Pages (from-to)949-955
Number of pages7
JournalNature Immunology
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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