Survival analysis of hispanics in a cohort of patients with hepatocellular carcinoma

Research output: Contribution to journalArticle

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Abstract

Background: Hepatocellular carcinoma (HCC) appears to have worse prognosis among Hispanics and other ethnic minorities in the United States. We investigated the overall survival (OS) of Hispanics with HCC and compared it with non-Hispanic (NH) whites and NH blacks.

Methods: Patients diagnosed and treated for HCC at an urban medical center between 2000 and 2011 were identified from the institutional cancer registry. A Cox proportional-hazard model was used to assess survival differences between Hispanics, NH whites, and NH blacks after adjusting for clinically and statistically significant variables.

Results: A total of 681 patients were identified, 24 of whom were excluded due to inability to confirm the diagnosis of HCC based on radiologic criteria and 24 due to unavailable ethnicity data. The remaining 633 patients were used for analysis. Of this final cohort, 49% (n5309) were Hispanic, 23% (n5144) were NH white, and 28% (n5180) were NH black. The median OS among Hispanics was 16.3 months and was similar to that of NH whites (14.0 months) and NH blacks (17.3 months) (P50.76). Multivariate analysis revealed a hazard ratio for death for His-panics of 0.78 (95% confidence interval 0.58-1.07, P5.12) when compared with NH whites and a hazard ratio for death of 0.89 (95% confidence interval 0.68-1.19, P50.46) when compared with NH blacks.

Conclusions: In contrast to previous reports, Hispanics with HCC from this cohort experienced similar OS when compared with NH whites and NH blacks.

Original languageEnglish (US)
Pages (from-to)3683-3690
Number of pages8
JournalCancer
Volume120
Issue number23
DOIs
StatePublished - Dec 1 2014

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Survival Analysis
Hispanic Americans
Hepatocellular Carcinoma
Survival
Confidence Intervals
Panic
Proportional Hazards Models
Registries
Multivariate Analysis
Neoplasms

Keywords

  • Ethnic minorities
  • Hepatocellular carcinoma
  • Hispanic
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Survival analysis of hispanics in a cohort of patients with hepatocellular carcinoma. / Aparo, Santiago; Goel, Sanjay; Lin, Daniel; Ohri, Nitin; Schwartz, Jonathan M.; Lo, Yungtai; Kaubisch, Andreas.

In: Cancer, Vol. 120, No. 23, 01.12.2014, p. 3683-3690.

Research output: Contribution to journalArticle

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abstract = "Background: Hepatocellular carcinoma (HCC) appears to have worse prognosis among Hispanics and other ethnic minorities in the United States. We investigated the overall survival (OS) of Hispanics with HCC and compared it with non-Hispanic (NH) whites and NH blacks.Methods: Patients diagnosed and treated for HCC at an urban medical center between 2000 and 2011 were identified from the institutional cancer registry. A Cox proportional-hazard model was used to assess survival differences between Hispanics, NH whites, and NH blacks after adjusting for clinically and statistically significant variables.Results: A total of 681 patients were identified, 24 of whom were excluded due to inability to confirm the diagnosis of HCC based on radiologic criteria and 24 due to unavailable ethnicity data. The remaining 633 patients were used for analysis. Of this final cohort, 49{\%} (n5309) were Hispanic, 23{\%} (n5144) were NH white, and 28{\%} (n5180) were NH black. The median OS among Hispanics was 16.3 months and was similar to that of NH whites (14.0 months) and NH blacks (17.3 months) (P50.76). Multivariate analysis revealed a hazard ratio for death for His-panics of 0.78 (95{\%} confidence interval 0.58-1.07, P5.12) when compared with NH whites and a hazard ratio for death of 0.89 (95{\%} confidence interval 0.68-1.19, P50.46) when compared with NH blacks.Conclusions: In contrast to previous reports, Hispanics with HCC from this cohort experienced similar OS when compared with NH whites and NH blacks.",
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T1 - Survival analysis of hispanics in a cohort of patients with hepatocellular carcinoma

AU - Aparo, Santiago

AU - Goel, Sanjay

AU - Lin, Daniel

AU - Ohri, Nitin

AU - Schwartz, Jonathan M.

AU - Lo, Yungtai

AU - Kaubisch, Andreas

PY - 2014/12/1

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N2 - Background: Hepatocellular carcinoma (HCC) appears to have worse prognosis among Hispanics and other ethnic minorities in the United States. We investigated the overall survival (OS) of Hispanics with HCC and compared it with non-Hispanic (NH) whites and NH blacks.Methods: Patients diagnosed and treated for HCC at an urban medical center between 2000 and 2011 were identified from the institutional cancer registry. A Cox proportional-hazard model was used to assess survival differences between Hispanics, NH whites, and NH blacks after adjusting for clinically and statistically significant variables.Results: A total of 681 patients were identified, 24 of whom were excluded due to inability to confirm the diagnosis of HCC based on radiologic criteria and 24 due to unavailable ethnicity data. The remaining 633 patients were used for analysis. Of this final cohort, 49% (n5309) were Hispanic, 23% (n5144) were NH white, and 28% (n5180) were NH black. The median OS among Hispanics was 16.3 months and was similar to that of NH whites (14.0 months) and NH blacks (17.3 months) (P50.76). Multivariate analysis revealed a hazard ratio for death for His-panics of 0.78 (95% confidence interval 0.58-1.07, P5.12) when compared with NH whites and a hazard ratio for death of 0.89 (95% confidence interval 0.68-1.19, P50.46) when compared with NH blacks.Conclusions: In contrast to previous reports, Hispanics with HCC from this cohort experienced similar OS when compared with NH whites and NH blacks.

AB - Background: Hepatocellular carcinoma (HCC) appears to have worse prognosis among Hispanics and other ethnic minorities in the United States. We investigated the overall survival (OS) of Hispanics with HCC and compared it with non-Hispanic (NH) whites and NH blacks.Methods: Patients diagnosed and treated for HCC at an urban medical center between 2000 and 2011 were identified from the institutional cancer registry. A Cox proportional-hazard model was used to assess survival differences between Hispanics, NH whites, and NH blacks after adjusting for clinically and statistically significant variables.Results: A total of 681 patients were identified, 24 of whom were excluded due to inability to confirm the diagnosis of HCC based on radiologic criteria and 24 due to unavailable ethnicity data. The remaining 633 patients were used for analysis. Of this final cohort, 49% (n5309) were Hispanic, 23% (n5144) were NH white, and 28% (n5180) were NH black. The median OS among Hispanics was 16.3 months and was similar to that of NH whites (14.0 months) and NH blacks (17.3 months) (P50.76). Multivariate analysis revealed a hazard ratio for death for His-panics of 0.78 (95% confidence interval 0.58-1.07, P5.12) when compared with NH whites and a hazard ratio for death of 0.89 (95% confidence interval 0.68-1.19, P50.46) when compared with NH blacks.Conclusions: In contrast to previous reports, Hispanics with HCC from this cohort experienced similar OS when compared with NH whites and NH blacks.

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