Surgical ventricular restoration and other surgical approaches to heart failure.

Patrick I. McConnell, Robert E. Michler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Historically, few patients with ischemic congestive heart failure (CHF) have been considered for cardiac surgical intervention unless there was an obvious need for coronary revascularization or valve repair. New surgical procedures and non-mechanical assist devices are being used and tested in patients with end-stage CHF. We report on The Ohio State University Medical Center's early involvement in the international and multi-institutional Surgical Treatment for Ischemic Heart Failure (STICH) trial, which is evaluating the value of coronary artery bypass in patients with ischemic CHF as compared to medical therapies alone, and whether surgical ventricular restoration (SVR) offers additional benefit to patients with dilated hearts undergoing revascularization. Beyond standard coronary revascularization and SVR, new surgically deployed devices that attempt to augment ventricular performance by direct restraint of left ventricular dilatation or by reducing ventricular wall stress through altering ventricular shape are reviewed. The growing clinical and experimental experience with cellular cardiomyoplasty (in particular, autologous skeletal myoblast and adult-derived stem transplantation) also is reviewed. This review is intended to express the institutional insights of the authors, who have been involved in clinical trials and basic science research in each of these areas.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalCurr Heart Fail Rep
Volume1
Issue number1
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Heart Failure
Cardiomyoplasty
Skeletal Myoblasts
Equipment and Supplies
Coronary Artery Bypass
Dilatation
Transplantation
Clinical Trials
Therapeutics
Research

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Emergency Medicine

Cite this

Surgical ventricular restoration and other surgical approaches to heart failure. / McConnell, Patrick I.; Michler, Robert E.

In: Curr Heart Fail Rep, Vol. 1, No. 1, 04.2004, p. 21-29.

Research output: Contribution to journalArticle

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