Surgical treatment of hepatocellular carcinoma beyond milan criteria. Results of liver resection, salvage transplantation, and primary liver transplantation

Marcelo E. Facciuto, Baburao Koneru, Juan P. Rocca, David C. Wolf, Leona Kim-Schluger, Paul Visintainer, Kenneth M. Klein, Hoo Chun, Michael Marvin, Grigory Rozenblit, Manuel Rodriguez-Davalos, Patricia A. Sheiner

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background: There is no clear consensus regarding the best treatment strategy for patients with advanced hepatocellular carcinoma (HCC). Methods: Patients with cirrhosis and HCC beyond Milan who had undergone liver resection (LR) or primary orthotopic liver transplantation (OLT) between November 1995 and December 2005 were included in this study. Pathological tumor staging was based on the American Liver Tumor Study Group modified Tumor-Node-Metastasis classification. Results: A total of 23 HCC patients were primarily treated by means of LR, 5 of whom eventually underwent salvage OLT. An additional 32 patients underwent primary OLT. The overall actuarial survival rates at 3 and 5 years were 35% after LR, and 69% and 60%, respectively, after primary OLT. Recurrence-free survival at 5 years was significantly higher after OLT (65%) than after LR (26%). Of the patients who underwent LR, 11 (48%) experienced HCC recurrence only in the liver; 6 of these 11 presented with advanced HCC recurrence, poor medical status, or short disease-free intervals and were not considered for transplantation. Salvage OLT was performed in 5 patients with early stage recurrence (45% of patients with hepatic recurrence after LR and 22% of all patients who underwent LR). At a median of 18 months after salvage OLT, all 5 patients are alive, 4 are free of disease, and 1 developed HCC recurrence 16 months after salvage OLT. Conclusion: For patients with HCC beyond Milan criteria, multimodality treatment-including LR, salvage OLT, and primary OLT-results in long-term survival in half of the patients. When indicated, LR can optimize the use of scarce donor organs by leaving OLT as a reserve option for early stage HCC recurrence.

Original languageEnglish (US)
Pages (from-to)1383-1391
Number of pages9
JournalAnnals of Surgical Oncology
Volume15
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

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Liver Transplantation
Hepatocellular Carcinoma
Transplantation
Liver
Recurrence
Therapeutics
Survival
Neoplasm Staging
Neoplasms
Fibrosis
Survival Rate
Tissue Donors
Neoplasm Metastasis

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Surgical treatment of hepatocellular carcinoma beyond milan criteria. Results of liver resection, salvage transplantation, and primary liver transplantation. / Facciuto, Marcelo E.; Koneru, Baburao; Rocca, Juan P.; Wolf, David C.; Kim-Schluger, Leona; Visintainer, Paul; Klein, Kenneth M.; Chun, Hoo; Marvin, Michael; Rozenblit, Grigory; Rodriguez-Davalos, Manuel; Sheiner, Patricia A.

In: Annals of Surgical Oncology, Vol. 15, No. 5, 05.2008, p. 1383-1391.

Research output: Contribution to journalArticle

Facciuto, ME, Koneru, B, Rocca, JP, Wolf, DC, Kim-Schluger, L, Visintainer, P, Klein, KM, Chun, H, Marvin, M, Rozenblit, G, Rodriguez-Davalos, M & Sheiner, PA 2008, 'Surgical treatment of hepatocellular carcinoma beyond milan criteria. Results of liver resection, salvage transplantation, and primary liver transplantation', Annals of Surgical Oncology, vol. 15, no. 5, pp. 1383-1391. https://doi.org/10.1245/s10434-008-9851-z
Facciuto, Marcelo E. ; Koneru, Baburao ; Rocca, Juan P. ; Wolf, David C. ; Kim-Schluger, Leona ; Visintainer, Paul ; Klein, Kenneth M. ; Chun, Hoo ; Marvin, Michael ; Rozenblit, Grigory ; Rodriguez-Davalos, Manuel ; Sheiner, Patricia A. / Surgical treatment of hepatocellular carcinoma beyond milan criteria. Results of liver resection, salvage transplantation, and primary liver transplantation. In: Annals of Surgical Oncology. 2008 ; Vol. 15, No. 5. pp. 1383-1391.
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abstract = "Background: There is no clear consensus regarding the best treatment strategy for patients with advanced hepatocellular carcinoma (HCC). Methods: Patients with cirrhosis and HCC beyond Milan who had undergone liver resection (LR) or primary orthotopic liver transplantation (OLT) between November 1995 and December 2005 were included in this study. Pathological tumor staging was based on the American Liver Tumor Study Group modified Tumor-Node-Metastasis classification. Results: A total of 23 HCC patients were primarily treated by means of LR, 5 of whom eventually underwent salvage OLT. An additional 32 patients underwent primary OLT. The overall actuarial survival rates at 3 and 5 years were 35{\%} after LR, and 69{\%} and 60{\%}, respectively, after primary OLT. Recurrence-free survival at 5 years was significantly higher after OLT (65{\%}) than after LR (26{\%}). Of the patients who underwent LR, 11 (48{\%}) experienced HCC recurrence only in the liver; 6 of these 11 presented with advanced HCC recurrence, poor medical status, or short disease-free intervals and were not considered for transplantation. Salvage OLT was performed in 5 patients with early stage recurrence (45{\%} of patients with hepatic recurrence after LR and 22{\%} of all patients who underwent LR). At a median of 18 months after salvage OLT, all 5 patients are alive, 4 are free of disease, and 1 developed HCC recurrence 16 months after salvage OLT. Conclusion: For patients with HCC beyond Milan criteria, multimodality treatment-including LR, salvage OLT, and primary OLT-results in long-term survival in half of the patients. When indicated, LR can optimize the use of scarce donor organs by leaving OLT as a reserve option for early stage HCC recurrence.",
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T1 - Surgical treatment of hepatocellular carcinoma beyond milan criteria. Results of liver resection, salvage transplantation, and primary liver transplantation

AU - Facciuto, Marcelo E.

AU - Koneru, Baburao

AU - Rocca, Juan P.

AU - Wolf, David C.

AU - Kim-Schluger, Leona

AU - Visintainer, Paul

AU - Klein, Kenneth M.

AU - Chun, Hoo

AU - Marvin, Michael

AU - Rozenblit, Grigory

AU - Rodriguez-Davalos, Manuel

AU - Sheiner, Patricia A.

PY - 2008/5

Y1 - 2008/5

N2 - Background: There is no clear consensus regarding the best treatment strategy for patients with advanced hepatocellular carcinoma (HCC). Methods: Patients with cirrhosis and HCC beyond Milan who had undergone liver resection (LR) or primary orthotopic liver transplantation (OLT) between November 1995 and December 2005 were included in this study. Pathological tumor staging was based on the American Liver Tumor Study Group modified Tumor-Node-Metastasis classification. Results: A total of 23 HCC patients were primarily treated by means of LR, 5 of whom eventually underwent salvage OLT. An additional 32 patients underwent primary OLT. The overall actuarial survival rates at 3 and 5 years were 35% after LR, and 69% and 60%, respectively, after primary OLT. Recurrence-free survival at 5 years was significantly higher after OLT (65%) than after LR (26%). Of the patients who underwent LR, 11 (48%) experienced HCC recurrence only in the liver; 6 of these 11 presented with advanced HCC recurrence, poor medical status, or short disease-free intervals and were not considered for transplantation. Salvage OLT was performed in 5 patients with early stage recurrence (45% of patients with hepatic recurrence after LR and 22% of all patients who underwent LR). At a median of 18 months after salvage OLT, all 5 patients are alive, 4 are free of disease, and 1 developed HCC recurrence 16 months after salvage OLT. Conclusion: For patients with HCC beyond Milan criteria, multimodality treatment-including LR, salvage OLT, and primary OLT-results in long-term survival in half of the patients. When indicated, LR can optimize the use of scarce donor organs by leaving OLT as a reserve option for early stage HCC recurrence.

AB - Background: There is no clear consensus regarding the best treatment strategy for patients with advanced hepatocellular carcinoma (HCC). Methods: Patients with cirrhosis and HCC beyond Milan who had undergone liver resection (LR) or primary orthotopic liver transplantation (OLT) between November 1995 and December 2005 were included in this study. Pathological tumor staging was based on the American Liver Tumor Study Group modified Tumor-Node-Metastasis classification. Results: A total of 23 HCC patients were primarily treated by means of LR, 5 of whom eventually underwent salvage OLT. An additional 32 patients underwent primary OLT. The overall actuarial survival rates at 3 and 5 years were 35% after LR, and 69% and 60%, respectively, after primary OLT. Recurrence-free survival at 5 years was significantly higher after OLT (65%) than after LR (26%). Of the patients who underwent LR, 11 (48%) experienced HCC recurrence only in the liver; 6 of these 11 presented with advanced HCC recurrence, poor medical status, or short disease-free intervals and were not considered for transplantation. Salvage OLT was performed in 5 patients with early stage recurrence (45% of patients with hepatic recurrence after LR and 22% of all patients who underwent LR). At a median of 18 months after salvage OLT, all 5 patients are alive, 4 are free of disease, and 1 developed HCC recurrence 16 months after salvage OLT. Conclusion: For patients with HCC beyond Milan criteria, multimodality treatment-including LR, salvage OLT, and primary OLT-results in long-term survival in half of the patients. When indicated, LR can optimize the use of scarce donor organs by leaving OLT as a reserve option for early stage HCC recurrence.

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