The design and synthesis of a silanated derivatives of tetraethylene glycol for biomedical applications were investigated. Silanated tetraethylene glycol (STEG) was synthesized by adding undecenyl moiety to TEG monoethyl ether under alkaline and air free conditions, resulting in the formation of an intermediate ether. Glass surfaces, pre-cleaned in a Nochromix solution, were modified by STEG. An immunofluorescence assay with slight modification was used to determine the relative amount of fibrinogen absorbed on modified and unmodified glass surfaces. Results show that silane is an effective agent for resisting protein adsorption.