Surface architecture of Histoplasma capsulatum

Allan J. Guimarães; Mariana D. de Cerqueira; Joshua D. Nosanchuk

doi:10.3389/fmicb.2011.00225

Surface architecture of Histoplasma capsulatum

Allan J. Guimarães, Mariana D. de Cerqueira, Joshua D. Nosanchuk

Medicine

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

The dimorphic fungal pathogen Histoplasma capsulatum is the most frequent cause of clinically significant fungal pneumonia in humans. H. capsulatum virulence is achieved, in part, through diverse and dynamic alterations to the fungal cell surface. Surface components associated with H. capsulatum pathogenicity include carbohydrates, lipids, proteins, and melanins. Here, we describe the various structures comprising the cell surface of H. capsulatum that have been associated with virulence and discuss their involvement in the pathobiology of disease.

Original language	English (US)
Journal	Frontiers in Microbiology
Volume	2
Issue number	NOV
DOIs	https://doi.org/10.3389/fmicb.2011.00225
State	Published - 2011

Keywords

Architecture
Carbohydrates
Cell wall
Histoplasma capsulatum
Proteins
Surface

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

Access to Document

10.3389/fmicb.2011.00225

Cite this

@article{0982d305c6144097899ac3d55b599c1e,

title = "Surface architecture of Histoplasma capsulatum",

abstract = "The dimorphic fungal pathogen Histoplasma capsulatum is the most frequent cause of clinically significant fungal pneumonia in humans. H. capsulatum virulence is achieved, in part, through diverse and dynamic alterations to the fungal cell surface. Surface components associated with H. capsulatum pathogenicity include carbohydrates, lipids, proteins, and melanins. Here, we describe the various structures comprising the cell surface of H. capsulatum that have been associated with virulence and discuss their involvement in the pathobiology of disease.",

keywords = "Architecture, Carbohydrates, Cell wall, Histoplasma capsulatum, Proteins, Surface",

author = "Guimar{\~a}es, {Allan J.} and {de Cerqueira}, {Mariana D.} and Nosanchuk, {Joshua D.}",

year = "2011",

doi = "10.3389/fmicb.2011.00225",

language = "English (US)",

volume = "2",

journal = "Frontiers in Microbiology",

issn = "1664-302X",

publisher = "Frontiers Media S. A.",

number = "NOV",

}

TY - JOUR

T1 - Surface architecture of Histoplasma capsulatum

AU - Guimarães, Allan J.

AU - de Cerqueira, Mariana D.

AU - Nosanchuk, Joshua D.

PY - 2011

Y1 - 2011

N2 - The dimorphic fungal pathogen Histoplasma capsulatum is the most frequent cause of clinically significant fungal pneumonia in humans. H. capsulatum virulence is achieved, in part, through diverse and dynamic alterations to the fungal cell surface. Surface components associated with H. capsulatum pathogenicity include carbohydrates, lipids, proteins, and melanins. Here, we describe the various structures comprising the cell surface of H. capsulatum that have been associated with virulence and discuss their involvement in the pathobiology of disease.

AB - The dimorphic fungal pathogen Histoplasma capsulatum is the most frequent cause of clinically significant fungal pneumonia in humans. H. capsulatum virulence is achieved, in part, through diverse and dynamic alterations to the fungal cell surface. Surface components associated with H. capsulatum pathogenicity include carbohydrates, lipids, proteins, and melanins. Here, we describe the various structures comprising the cell surface of H. capsulatum that have been associated with virulence and discuss their involvement in the pathobiology of disease.

KW - Architecture

KW - Carbohydrates

KW - Cell wall

KW - Histoplasma capsulatum

KW - Proteins

KW - Surface

UR - http://www.scopus.com/inward/record.url?scp=84857873553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857873553&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2011.00225

DO - 10.3389/fmicb.2011.00225

M3 - Review article

C2 - 22121356

AN - SCOPUS:84857873553

SN - 1664-302X

VL - 2

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

IS - NOV

ER -

Surface architecture of Histoplasma capsulatum

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this