Supra-Plasma Expanders: The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?

Amy G. Tsai, Beatriz Y Salazar Vázquez, Axel Hofmann, Seetharama A. Acharya, Marcos Intaglietta

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolved. Anemia decreases oxygen-carrying capacity and blood viscosity. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygen-carrying capacity, thus treating the effects of anemia while avoiding the transfusion of blood.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalJournal of Infusion Nursing
Volume38
Issue number3
DOIs
StatePublished - Dec 1 2015

Fingerprint

Anemia
Oxygen
Conservation of Natural Resources
Blood Viscosity
Blood Transfusion
Perfusion
Tissue Expansion Devices
Blood Substitutes
Viscosity
Cardiac Output
Safety

Keywords

  • blood transfusion
  • hemorrhage
  • microcirculation
  • microvascular perfusion
  • oxygen delivery
  • oxygen transport
  • transfusion alternatives

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Supra-Plasma Expanders : The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions? / Tsai, Amy G.; Vázquez, Beatriz Y Salazar; Hofmann, Axel; Acharya, Seetharama A.; Intaglietta, Marcos.

In: Journal of Infusion Nursing, Vol. 38, No. 3, 01.12.2015, p. 217-222.

Research output: Contribution to journalArticle

Tsai, Amy G. ; Vázquez, Beatriz Y Salazar ; Hofmann, Axel ; Acharya, Seetharama A. ; Intaglietta, Marcos. / Supra-Plasma Expanders : The Future of Treating Blood Loss and Anemia Without Red Cell Transfusions?. In: Journal of Infusion Nursing. 2015 ; Vol. 38, No. 3. pp. 217-222.
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