It is shown that a population of cells exists in the spleen of 6 week old NZB/W mice, capable of suppressing the GVH reactivity of 25 week old spleen cells. Thymus cells of 6 week old NZB/W mice also suppressed the GVH response. Two T cells (effector and amplifier) have previously been shown to cooperate in the GVH reaction. Although a number of interpretations may be offered, one possibility is that a third type of T cell, a suppressor cell, may also be involved in the regulation of this cell mediated immune reaction.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of Immunology|
|State||Published - Jan 1 1973|
ASJC Scopus subject areas
- Immunology and Allergy