Suppression of renal inflammation with vitamins A and E in ascending pyelonephritis in rats

Robert T. Bennett, Richard J. Mazzaccaro, Neeru Chopra, Arnold Melman, Israel Franco

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Purpose: We evaluated the effects of vitamin A and E supplementation alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) on the development of inflammation in an animal model of ascending pyelonephritis. Materials and Methods: Ascending pyelonephritis was induced in adult rats by surgical bladder inoculation with P-pili-forming Escherichia coli. Treatment of pyelonephritic rats was initiated at 72 hours post- infection. Treatment groups included no treatment, or a five day regimen of antibiotic only, antibiotic plus vitamins A and E, or antibiotic, vitamins and either of two NSAIDs. Kidneys were harvested at six weeks post-infection and assessed for histopathologic inflammation. Results: Antibiotic treatment of pyelonephritic rats with vitamins A and E alone or in combination with NSAIDs resulted in significantly less kidney inflammation, as compared with untreated rats or rats treated with antibiotic alone. There was no significant difference in inflammation between animals treated with vitamins alone or vitamins plus NSAIDs. Conclusions: Antibiotic therapy and diet supplementation with vitamins A and E can significantly reduce the inflammation associated with ascending pyelonephritis, suggesting a potential use in the medical management of reflux nephropathy in children.

Original languageEnglish (US)
Pages (from-to)1681-1684
Number of pages4
JournalJournal of Urology
Volume161
Issue number5
DOIs
StatePublished - May 1999
Externally publishedYes

Fingerprint

Pyelonephritis
Vitamin A
Vitamin E
Anti-Bacterial Agents
Inflammation
Kidney
Anti-Inflammatory Agents
Vitamins
Pharmaceutical Preparations
Diet Therapy
Therapeutics
Infection
Urinary Bladder
Animal Models
Escherichia coli

Keywords

  • Pyelonephritis
  • Vesico-ureteral reflux
  • Vitamin A
  • Vitamin E

ASJC Scopus subject areas

  • Urology

Cite this

Bennett, R. T., Mazzaccaro, R. J., Chopra, N., Melman, A., & Franco, I. (1999). Suppression of renal inflammation with vitamins A and E in ascending pyelonephritis in rats. Journal of Urology, 161(5), 1681-1684. https://doi.org/10.1016/S0022-5347(05)69004-0

Suppression of renal inflammation with vitamins A and E in ascending pyelonephritis in rats. / Bennett, Robert T.; Mazzaccaro, Richard J.; Chopra, Neeru; Melman, Arnold; Franco, Israel.

In: Journal of Urology, Vol. 161, No. 5, 05.1999, p. 1681-1684.

Research output: Contribution to journalArticle

Bennett, RT, Mazzaccaro, RJ, Chopra, N, Melman, A & Franco, I 1999, 'Suppression of renal inflammation with vitamins A and E in ascending pyelonephritis in rats', Journal of Urology, vol. 161, no. 5, pp. 1681-1684. https://doi.org/10.1016/S0022-5347(05)69004-0
Bennett, Robert T. ; Mazzaccaro, Richard J. ; Chopra, Neeru ; Melman, Arnold ; Franco, Israel. / Suppression of renal inflammation with vitamins A and E in ascending pyelonephritis in rats. In: Journal of Urology. 1999 ; Vol. 161, No. 5. pp. 1681-1684.
@article{be43dcba41d443c7be4334ced65501c8,
title = "Suppression of renal inflammation with vitamins A and E in ascending pyelonephritis in rats",
abstract = "Purpose: We evaluated the effects of vitamin A and E supplementation alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) on the development of inflammation in an animal model of ascending pyelonephritis. Materials and Methods: Ascending pyelonephritis was induced in adult rats by surgical bladder inoculation with P-pili-forming Escherichia coli. Treatment of pyelonephritic rats was initiated at 72 hours post- infection. Treatment groups included no treatment, or a five day regimen of antibiotic only, antibiotic plus vitamins A and E, or antibiotic, vitamins and either of two NSAIDs. Kidneys were harvested at six weeks post-infection and assessed for histopathologic inflammation. Results: Antibiotic treatment of pyelonephritic rats with vitamins A and E alone or in combination with NSAIDs resulted in significantly less kidney inflammation, as compared with untreated rats or rats treated with antibiotic alone. There was no significant difference in inflammation between animals treated with vitamins alone or vitamins plus NSAIDs. Conclusions: Antibiotic therapy and diet supplementation with vitamins A and E can significantly reduce the inflammation associated with ascending pyelonephritis, suggesting a potential use in the medical management of reflux nephropathy in children.",
keywords = "Pyelonephritis, Vesico-ureteral reflux, Vitamin A, Vitamin E",
author = "Bennett, {Robert T.} and Mazzaccaro, {Richard J.} and Neeru Chopra and Arnold Melman and Israel Franco",
year = "1999",
month = "5",
doi = "10.1016/S0022-5347(05)69004-0",
language = "English (US)",
volume = "161",
pages = "1681--1684",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Suppression of renal inflammation with vitamins A and E in ascending pyelonephritis in rats

AU - Bennett, Robert T.

AU - Mazzaccaro, Richard J.

AU - Chopra, Neeru

AU - Melman, Arnold

AU - Franco, Israel

PY - 1999/5

Y1 - 1999/5

N2 - Purpose: We evaluated the effects of vitamin A and E supplementation alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) on the development of inflammation in an animal model of ascending pyelonephritis. Materials and Methods: Ascending pyelonephritis was induced in adult rats by surgical bladder inoculation with P-pili-forming Escherichia coli. Treatment of pyelonephritic rats was initiated at 72 hours post- infection. Treatment groups included no treatment, or a five day regimen of antibiotic only, antibiotic plus vitamins A and E, or antibiotic, vitamins and either of two NSAIDs. Kidneys were harvested at six weeks post-infection and assessed for histopathologic inflammation. Results: Antibiotic treatment of pyelonephritic rats with vitamins A and E alone or in combination with NSAIDs resulted in significantly less kidney inflammation, as compared with untreated rats or rats treated with antibiotic alone. There was no significant difference in inflammation between animals treated with vitamins alone or vitamins plus NSAIDs. Conclusions: Antibiotic therapy and diet supplementation with vitamins A and E can significantly reduce the inflammation associated with ascending pyelonephritis, suggesting a potential use in the medical management of reflux nephropathy in children.

AB - Purpose: We evaluated the effects of vitamin A and E supplementation alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) on the development of inflammation in an animal model of ascending pyelonephritis. Materials and Methods: Ascending pyelonephritis was induced in adult rats by surgical bladder inoculation with P-pili-forming Escherichia coli. Treatment of pyelonephritic rats was initiated at 72 hours post- infection. Treatment groups included no treatment, or a five day regimen of antibiotic only, antibiotic plus vitamins A and E, or antibiotic, vitamins and either of two NSAIDs. Kidneys were harvested at six weeks post-infection and assessed for histopathologic inflammation. Results: Antibiotic treatment of pyelonephritic rats with vitamins A and E alone or in combination with NSAIDs resulted in significantly less kidney inflammation, as compared with untreated rats or rats treated with antibiotic alone. There was no significant difference in inflammation between animals treated with vitamins alone or vitamins plus NSAIDs. Conclusions: Antibiotic therapy and diet supplementation with vitamins A and E can significantly reduce the inflammation associated with ascending pyelonephritis, suggesting a potential use in the medical management of reflux nephropathy in children.

KW - Pyelonephritis

KW - Vesico-ureteral reflux

KW - Vitamin A

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=0032824360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032824360&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(05)69004-0

DO - 10.1016/S0022-5347(05)69004-0

M3 - Article

C2 - 10210439

AN - SCOPUS:0032824360

VL - 161

SP - 1681

EP - 1684

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 5

ER -