Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway

Xiaobo Li, Hongbao Yang, Shenshen Wu, Qingtao Meng, Hao Sun, Runze Lu, Jian Cui, Yuxin Zheng, Wen Chen, Rong Zhang, Michael Aschner, Rui Chen

Research output: Contribution to journalArticle

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Abstract

Background: Inhaled nanoparticles can deposit in the deep lung where they interact with pulmonary cells. Despite numerous studies on pulmonary nanotoxicity, detailed molecular mechanisms of specific nanomaterial-induced lung injury have yet to be identified. Results: Using whole-body dynamic inhalation model, we studied the interactions between aluminum oxide nanoparticles (Al2O3 NPs) and the pulmonary system in vivo. We found that seven-day-exposure to Al2O3 NPs resulted in emphysema and small airway remodeling in murine lungs, accompanied by enhanced inflammation and apoptosis. Al2O3 NPs exposure led to suppression of PTPN6 and phosphorylation of STAT3, culminating in increased expression of the apoptotic marker PDCD4. Rescue of PTPN6 expression or application of a STAT3 inhibitor, effectively protected murine lungs from inflammation and apoptosis, as well as, in part, from the induction of chronic obstructive pulmonary disease (COPD)-like effects. Conclusion: In summary, our studies show that inhibition of PTPN6 plays a critical role in Al2O3 NPs-induced COPD-like lesions.

Original languageEnglish (US)
Article number53
JournalParticle and Fibre Toxicology
Volume14
Issue number1
DOIs
StatePublished - Dec 12 2017

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Pulmonary diseases
Aluminum Oxide
Nanoparticles
Chronic Obstructive Pulmonary Disease
Chemical activation
Apoptosis
Lung
Phosphorylation
Nanostructured materials
Dynamic models
Deposits
Airway Remodeling
Nanostructures
Emphysema
Lung Injury
Inhalation
Pneumonia
Inflammation

Keywords

  • Aluminum oxide nanoparticles
  • Experimental COPD
  • Inflammation
  • PTPN6

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway. / Li, Xiaobo; Yang, Hongbao; Wu, Shenshen; Meng, Qingtao; Sun, Hao; Lu, Runze; Cui, Jian; Zheng, Yuxin; Chen, Wen; Zhang, Rong; Aschner, Michael; Chen, Rui.

In: Particle and Fibre Toxicology, Vol. 14, No. 1, 53, 12.12.2017.

Research output: Contribution to journalArticle

Li, Xiaobo ; Yang, Hongbao ; Wu, Shenshen ; Meng, Qingtao ; Sun, Hao ; Lu, Runze ; Cui, Jian ; Zheng, Yuxin ; Chen, Wen ; Zhang, Rong ; Aschner, Michael ; Chen, Rui. / Suppression of PTPN6 exacerbates aluminum oxide nanoparticle-induced COPD-like lesions in mice through activation of STAT pathway. In: Particle and Fibre Toxicology. 2017 ; Vol. 14, No. 1.
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AU - Lu, Runze

AU - Cui, Jian

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AB - Background: Inhaled nanoparticles can deposit in the deep lung where they interact with pulmonary cells. Despite numerous studies on pulmonary nanotoxicity, detailed molecular mechanisms of specific nanomaterial-induced lung injury have yet to be identified. Results: Using whole-body dynamic inhalation model, we studied the interactions between aluminum oxide nanoparticles (Al2O3 NPs) and the pulmonary system in vivo. We found that seven-day-exposure to Al2O3 NPs resulted in emphysema and small airway remodeling in murine lungs, accompanied by enhanced inflammation and apoptosis. Al2O3 NPs exposure led to suppression of PTPN6 and phosphorylation of STAT3, culminating in increased expression of the apoptotic marker PDCD4. Rescue of PTPN6 expression or application of a STAT3 inhibitor, effectively protected murine lungs from inflammation and apoptosis, as well as, in part, from the induction of chronic obstructive pulmonary disease (COPD)-like effects. Conclusion: In summary, our studies show that inhibition of PTPN6 plays a critical role in Al2O3 NPs-induced COPD-like lesions.

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