TY - JOUR
T1 - Suppression of human lymphocyte DNA and protein synthesis in vitro by adenosine and eight modified adenine nucleosides in the presence or in the absence of adenosine deaminase inhibitors, 2′-deoxycoformycin (DCF) and erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA)
AU - Ratech, Howard
AU - Kuritsky, Lloyd
AU - Thorbecke, G. Jeanette
AU - Hirschhorn, Rochelle
N1 - Funding Information:
’ This work was supported by NIH AI 10343 and National Foundation 6-4. Howard Ratech was supported by a Pharmaceutical Manufacturers Association Fellowship.
PY - 1982/4
Y1 - 1982/4
N2 - Adenosine and eight modified adenine nucleosides in the presence or in the absence of adenosine deaminase (ADA) inhibitors, 2′-deoxycoformycin or erythro-9-(2-hydroxy-3-nonyl) adenine, were investigated with regard to their effects on phytohemagglutinin-stimulated human lymphocytes in vitro. Protein and DNA synthesis were inhibited depending upon the specific nucleoside, presence or absence of ADA inhibitor, and time of addition of nucleoside to cultures. A possible role for the modified adenine nucleosides in causing in vivo immunodeficiency is proposed.
AB - Adenosine and eight modified adenine nucleosides in the presence or in the absence of adenosine deaminase (ADA) inhibitors, 2′-deoxycoformycin or erythro-9-(2-hydroxy-3-nonyl) adenine, were investigated with regard to their effects on phytohemagglutinin-stimulated human lymphocytes in vitro. Protein and DNA synthesis were inhibited depending upon the specific nucleoside, presence or absence of ADA inhibitor, and time of addition of nucleoside to cultures. A possible role for the modified adenine nucleosides in causing in vivo immunodeficiency is proposed.
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U2 - 10.1016/0008-8749(82)90109-5
DO - 10.1016/0008-8749(82)90109-5
M3 - Article
C2 - 6980056
AN - SCOPUS:0020066329
SN - 0008-8749
VL - 68
SP - 244
EP - 251
JO - Cellular Immunology
JF - Cellular Immunology
IS - 2
ER -