Suppression of adjuvant arthritis by κ-opioid receptor agonist: Effect of route of administration and strain differences

Jelena Antić, Tatjana Vasiljević, Stanislava Stanojević, Vesna Vujić, Vesna Kovačević-Jovanović, Danica Djergović, Čedo Miljević, Branislav M. Marković, Jelena Radulović

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

It is well established that κ-opioid receptor agonists exert antiinflammatory and antihyperalgesic effects during nonspecific inflammation as well as suppressive effects on the development of humoral and cell-mediated immune responses to foreign antigens. The aim of this study was to investigate the ability of the κ-opioid receptor agonist MR 2034 to modulate adjuvant arthritis in the rat. In the first series of experiments, treatments of Wistar rats were performed using several routes of drug administration: intraperitoneal (ip), intracaudal (ic), intracerebroventricular (icv) and intraplantar (ipl). MR 2034 significantly suppressed joint swelling after ip and ic treatment, slightly reduced inflammation after ipl treatment, and did not produce any effect after icv treatment. In the second series of experiments, the suppressive effect of ip injected MR 2034 was investigated using Wistar, Dark August (DA) and Lewis rats. In Wistar rats, MR 2034 significantly decreased the incidence of adjuvant arthritis, and suppressed mean joint score and aggregate joint score. Similarly, in DA rats treated with MR 2034, mean arthritic score was significantly suppressed, but other clinical parameters were not affected. In Lewis rats, however, ip treatment with MR 2034 failed to produce any suppressive effect on joint disease and even potentiated the initial development of arthritis. These data suggest that immunosuppressive and antiinflammatory action of MR 2034 markedly depend on the route of drug administration and strain susceptibility to opioids.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalImmunopharmacology
Volume34
Issue number2-3
DOIs
StatePublished - Sep 1996
Externally publishedYes

Keywords

  • Adjuvant arthritis
  • Immunosuppression
  • Rat strains
  • κ-Opioid agonist

ASJC Scopus subject areas

  • Pharmacology

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