Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

Ann Tempel; R. Suzanne Zukin; Eliot L. Gardner

doi:10.1016/0024-3205(82)90391-5

Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

Ann Tempel, R. Suzanne Zukin, Eliot L. Gardner

Neuroscience

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Chronic administration of the narcotic antagonist naltrexone resulted in a marked increase in brain opiate receptors. Similar changes were observed for putative Mu, Delta, and Kappa opiate receptor subtypes. In contrast, only a modest increase was observed for the putative Sigma receptor. Withdrawal from chronic naltrexone treatment resulted in a decrease from elevated receptor levels to nearly control receptors levels in a period of about 6 days, as revealed by [³H] etorphine binding. These results may shed light on the mechanisms of opiate dependence and withdrawal.

Original language	English (US)
Pages (from-to)	1401-1404
Number of pages	4
Journal	Life Sciences
Volume	31
Issue number	12-13
DOIs	https://doi.org/10.1016/0024-3205(82)90391-5
State	Published - Sep 1982

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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abstract = "Chronic administration of the narcotic antagonist naltrexone resulted in a marked increase in brain opiate receptors. Similar changes were observed for putative Mu, Delta, and Kappa opiate receptor subtypes. In contrast, only a modest increase was observed for the putative Sigma receptor. Withdrawal from chronic naltrexone treatment resulted in a decrease from elevated receptor levels to nearly control receptors levels in a period of about 6 days, as revealed by [3H] etorphine binding. These results may shed light on the mechanisms of opiate dependence and withdrawal.",

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year = "1982",

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AU - Zukin, R. Suzanne

AU - Gardner, Eliot L.

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N2 - Chronic administration of the narcotic antagonist naltrexone resulted in a marked increase in brain opiate receptors. Similar changes were observed for putative Mu, Delta, and Kappa opiate receptor subtypes. In contrast, only a modest increase was observed for the putative Sigma receptor. Withdrawal from chronic naltrexone treatment resulted in a decrease from elevated receptor levels to nearly control receptors levels in a period of about 6 days, as revealed by [3H] etorphine binding. These results may shed light on the mechanisms of opiate dependence and withdrawal.

AB - Chronic administration of the narcotic antagonist naltrexone resulted in a marked increase in brain opiate receptors. Similar changes were observed for putative Mu, Delta, and Kappa opiate receptor subtypes. In contrast, only a modest increase was observed for the putative Sigma receptor. Withdrawal from chronic naltrexone treatment resulted in a decrease from elevated receptor levels to nearly control receptors levels in a period of about 6 days, as revealed by [3H] etorphine binding. These results may shed light on the mechanisms of opiate dependence and withdrawal.

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Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

Abstract

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