99mTc-MAA vs. 68Ga-MAA as perfusion agents

Alejandro Amor-Coarasa, Andrew Milera, Denny A. Carvajal, Anthony J. McGoron

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The use of 99mTc Macroaggregated Albumin (MAA) as a perfusion agent has been evaluated since 1965. With the advent of Positron Emission Tomography (PET), an initial attempt to produce pharmaceutical grade 68Ga-MAA was successfully performed in 1989. However, a comparison of both perfusion agents, beyond the advantages of PET over Single Photon Emission Tomography (SPET) has not been performed to date. Both 99mTc-MAA and 68Ga-MAA were used to perform lung perfusion studies in male Sprague Dawley rats. Images were taken at several time points. Animals were euthanized at 2 and 4 hours, organs collected and biodistribution determined. Biodistribution of both agents was very similar within the first hour; however, 99mTc is released from the MAA after the first hour and it is excreted into the urine. 68Ga-MAA remains stable until 68Ga decays and more than 95% of the injected activity is concentrated in lungs. The previously reported 6 hour "in vivo" half-life of MAA is challenged. Both imaging agents are suitable for lung perfusion studies. However, the observed half-life of MAA, greater than 6 hours, has significant implication for other applications. 68Ga- MAA is introduced as a possible candidate for Selective Internal Radiation Treatment Planning agent.

Original languageEnglish (US)
Title of host publicationProceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013
Pages131-132
Number of pages2
DOIs
Publication statusPublished - Aug 5 2013
Externally publishedYes
Event29th Southern Biomedical Engineering Conference, SBEC 2013 - Miami, FL, United States
Duration: May 3 2013May 5 2013

Publication series

NameProceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013

Conference

Conference29th Southern Biomedical Engineering Conference, SBEC 2013
CountryUnited States
CityMiami, FL
Period5/3/135/5/13

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ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Amor-Coarasa, A., Milera, A., Carvajal, D. A., & McGoron, A. J. (2013). 99mTc-MAA vs. 68Ga-MAA as perfusion agents. In Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013 (pp. 131-132). [6525711] (Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013). https://doi.org/10.1109/SBEC.2013.74