TY - JOUR
T1 - Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens
AU - Herold, Betsy C.
AU - Siston, Alicia
AU - Bremer, James
AU - Kirkpatrick, Risa
AU - Wilbanks, George
AU - Fugedi, Peter
AU - Peto, Csaba
AU - Cooper, Morris
PY - 1997/12
Y1 - 1997/12
N2 - Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.
AB - Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.
UR - http://www.scopus.com/inward/record.url?scp=0030732295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030732295&partnerID=8YFLogxK
U2 - 10.1128/aac.41.12.2776
DO - 10.1128/aac.41.12.2776
M3 - Comment/debate
C2 - 9420059
AN - SCOPUS:0030732295
SN - 0066-4804
VL - 41
SP - 2776
EP - 2780
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 12
ER -
