Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens

Betsy C. Herold, Alicia Siston, James Bremer, Risa Kirkpatrick, George Wilbanks, Peter Fugedi, Csaba Peto, Morris Cooper

Research output: Contribution to journalComment/debate

54 Scopus citations

Abstract

Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.

Original languageEnglish (US)
Pages (from-to)2776-2780
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume41
Issue number12
DOIs
StatePublished - Dec 1997
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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