Sugar-derived glasses support thermal and photo-initiated electron transfer processes over macroscopic distances

Mahantesh S. Navati, Joel M. Friedman

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Trehalose-derived glasses are shown to support long range electron transfer reactions between spatially well separated donors and protein acceptors. The results indicate that these matrices can be used not only to greatly stabilize protein structures but also to facilitate both thermal and photo-initiated hemeprotein reduction over large macroscopic distances. To date the promise of exciting new protein-based technologies that can harness the exceptional tunability of protein functionality has been significantly thwarted by both intrinsic instability and stringent solvent/environment requirements for the expression of functional properties. The presented results raise the prospect of overcoming these limitations with respect to incorporating redox active proteins into solid state devices such as tunable batteries, switches, and solar cells. The findings also have implications for formulations intended to enhance long term storage of biomaterials, new protein-based synthetic strategies, and biophysical studies of functional intermediates trapped under nonequilibrium conditions. In addition, the study shows that certain sugars such as glucose or tagatose, when added to redox-inactive glassy matrices, can be used as a source of thermal electrons that can be harvested by suitable redox active proteins, raising the prospect of using common sugars as an electron source in solid state thermal fuel cells.

Original languageEnglish (US)
Pages (from-to)36021-36028
Number of pages8
JournalJournal of Biological Chemistry
Volume281
Issue number47
DOIs
StatePublished - Nov 24 2006

Fingerprint

Sugars
Glass
Hot Temperature
Electrons
Proteins
Oxidation-Reduction
Hemeproteins
Solid state devices
Electron sources
Trehalose
Biocompatible Materials
Fuel cells
Solar cells
Switches
Technology
Glucose
Equipment and Supplies

ASJC Scopus subject areas

  • Biochemistry

Cite this

Sugar-derived glasses support thermal and photo-initiated electron transfer processes over macroscopic distances. / Navati, Mahantesh S.; Friedman, Joel M.

In: Journal of Biological Chemistry, Vol. 281, No. 47, 24.11.2006, p. 36021-36028.

Research output: Contribution to journalArticle

@article{cc9d928e2c614267915321c5aa658300,
title = "Sugar-derived glasses support thermal and photo-initiated electron transfer processes over macroscopic distances",
abstract = "Trehalose-derived glasses are shown to support long range electron transfer reactions between spatially well separated donors and protein acceptors. The results indicate that these matrices can be used not only to greatly stabilize protein structures but also to facilitate both thermal and photo-initiated hemeprotein reduction over large macroscopic distances. To date the promise of exciting new protein-based technologies that can harness the exceptional tunability of protein functionality has been significantly thwarted by both intrinsic instability and stringent solvent/environment requirements for the expression of functional properties. The presented results raise the prospect of overcoming these limitations with respect to incorporating redox active proteins into solid state devices such as tunable batteries, switches, and solar cells. The findings also have implications for formulations intended to enhance long term storage of biomaterials, new protein-based synthetic strategies, and biophysical studies of functional intermediates trapped under nonequilibrium conditions. In addition, the study shows that certain sugars such as glucose or tagatose, when added to redox-inactive glassy matrices, can be used as a source of thermal electrons that can be harvested by suitable redox active proteins, raising the prospect of using common sugars as an electron source in solid state thermal fuel cells.",
author = "Navati, {Mahantesh S.} and Friedman, {Joel M.}",
year = "2006",
month = "11",
day = "24",
doi = "10.1074/jbc.M606866200",
language = "English (US)",
volume = "281",
pages = "36021--36028",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "47",

}

TY - JOUR

T1 - Sugar-derived glasses support thermal and photo-initiated electron transfer processes over macroscopic distances

AU - Navati, Mahantesh S.

AU - Friedman, Joel M.

PY - 2006/11/24

Y1 - 2006/11/24

N2 - Trehalose-derived glasses are shown to support long range electron transfer reactions between spatially well separated donors and protein acceptors. The results indicate that these matrices can be used not only to greatly stabilize protein structures but also to facilitate both thermal and photo-initiated hemeprotein reduction over large macroscopic distances. To date the promise of exciting new protein-based technologies that can harness the exceptional tunability of protein functionality has been significantly thwarted by both intrinsic instability and stringent solvent/environment requirements for the expression of functional properties. The presented results raise the prospect of overcoming these limitations with respect to incorporating redox active proteins into solid state devices such as tunable batteries, switches, and solar cells. The findings also have implications for formulations intended to enhance long term storage of biomaterials, new protein-based synthetic strategies, and biophysical studies of functional intermediates trapped under nonequilibrium conditions. In addition, the study shows that certain sugars such as glucose or tagatose, when added to redox-inactive glassy matrices, can be used as a source of thermal electrons that can be harvested by suitable redox active proteins, raising the prospect of using common sugars as an electron source in solid state thermal fuel cells.

AB - Trehalose-derived glasses are shown to support long range electron transfer reactions between spatially well separated donors and protein acceptors. The results indicate that these matrices can be used not only to greatly stabilize protein structures but also to facilitate both thermal and photo-initiated hemeprotein reduction over large macroscopic distances. To date the promise of exciting new protein-based technologies that can harness the exceptional tunability of protein functionality has been significantly thwarted by both intrinsic instability and stringent solvent/environment requirements for the expression of functional properties. The presented results raise the prospect of overcoming these limitations with respect to incorporating redox active proteins into solid state devices such as tunable batteries, switches, and solar cells. The findings also have implications for formulations intended to enhance long term storage of biomaterials, new protein-based synthetic strategies, and biophysical studies of functional intermediates trapped under nonequilibrium conditions. In addition, the study shows that certain sugars such as glucose or tagatose, when added to redox-inactive glassy matrices, can be used as a source of thermal electrons that can be harvested by suitable redox active proteins, raising the prospect of using common sugars as an electron source in solid state thermal fuel cells.

UR - http://www.scopus.com/inward/record.url?scp=33846013259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846013259&partnerID=8YFLogxK

U2 - 10.1074/jbc.M606866200

DO - 10.1074/jbc.M606866200

M3 - Article

C2 - 17005567

AN - SCOPUS:33846013259

VL - 281

SP - 36021

EP - 36028

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 47

ER -