Sudden cardiac death in heart failure: The role of abnormal repolarization

Gordon F. Tomaselli, Dirk J. Beuckelmann, Hugh G. Calkins, Ronald D. Berger, Paul D. Kessler, John H. Lawrence, David Kass, Arthur M. Feldman, Eduardo Marban

Research output: Contribution to journalReview article

352 Citations (Scopus)

Abstract

Congestive heart failure is a common, highly lethal cardiovascular disorder claiming over 200 000 lives a year in the United States alone. Some 50% of the deaths in heart failure patients are sudden, and most of these are probably the result of ventricular tachyarrhythmias. Methods designed to identify patients at risk have been remarkably unrewarding, as have attempts to intervene and prevent sudden death in these patients. The failure to impact favorably on the incidence of sudden death in heart failure patients stems largely from a lack of understanding of the underlying mechanisms of arrhythmogenesis. This article explores the role of abnormalities of ventricular repolarization in heart failure patients. We will examine evidence for the hypothesis that alteration of repolarizing K+ channel expression in failing myocardium predisposes to abnormalities in repolarization that are arrhythmogenic. The possible utility of novel electrophysiological and ECG measures of altered ventricular repolarization will be explored. Understanding the mechanism of sudden death in heart failure may lead to effective therapy and more accurate identification of patients at greatest risk.

Original languageEnglish (US)
Pages (from-to)2534-2539
Number of pages6
JournalCirculation
Volume90
Issue number5
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Heart Failure
Sudden Death
Tachycardia
Myocardium
Electrocardiography
Incidence

Keywords

  • action potentials
  • heart failure
  • tachyarrhythmias
  • tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Tomaselli, G. F., Beuckelmann, D. J., Calkins, H. G., Berger, R. D., Kessler, P. D., Lawrence, J. H., ... Marban, E. (1994). Sudden cardiac death in heart failure: The role of abnormal repolarization. Circulation, 90(5), 2534-2539. https://doi.org/10.1161/01.CIR.90.5.2534

Sudden cardiac death in heart failure : The role of abnormal repolarization. / Tomaselli, Gordon F.; Beuckelmann, Dirk J.; Calkins, Hugh G.; Berger, Ronald D.; Kessler, Paul D.; Lawrence, John H.; Kass, David; Feldman, Arthur M.; Marban, Eduardo.

In: Circulation, Vol. 90, No. 5, 01.01.1994, p. 2534-2539.

Research output: Contribution to journalReview article

Tomaselli, GF, Beuckelmann, DJ, Calkins, HG, Berger, RD, Kessler, PD, Lawrence, JH, Kass, D, Feldman, AM & Marban, E 1994, 'Sudden cardiac death in heart failure: The role of abnormal repolarization', Circulation, vol. 90, no. 5, pp. 2534-2539. https://doi.org/10.1161/01.CIR.90.5.2534
Tomaselli GF, Beuckelmann DJ, Calkins HG, Berger RD, Kessler PD, Lawrence JH et al. Sudden cardiac death in heart failure: The role of abnormal repolarization. Circulation. 1994 Jan 1;90(5):2534-2539. https://doi.org/10.1161/01.CIR.90.5.2534
Tomaselli, Gordon F. ; Beuckelmann, Dirk J. ; Calkins, Hugh G. ; Berger, Ronald D. ; Kessler, Paul D. ; Lawrence, John H. ; Kass, David ; Feldman, Arthur M. ; Marban, Eduardo. / Sudden cardiac death in heart failure : The role of abnormal repolarization. In: Circulation. 1994 ; Vol. 90, No. 5. pp. 2534-2539.
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