Successful treatment of a left ventricular assist device infection with daptomycin non-susceptible methicillin-resistant Staphylococcus aureus: Case report and review of the literature

D. T. Levy, M. E. Steed, M. J. Rybak, Y. Guo, Philip Gialanella, L. Hanau, V. Muggia, B. Ostrowsky

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Recipients of left ventricular assist devices (LVADs) are highly susceptible to the development of infections with multidrug- resistant (MDR) organisms. We describe the case of a patient with an LVAD who developed a device-related, daptomycin non-susceptible, methicillin-resistant Staphylococcus aureus infection, highlighting this patient population as highly vulnerable to the development of such antimicrobial resistance. This report includes a thorough review of the literature on the mechanisms of development of daptomycin non-susceptibility and suggests ways to prevent its emergence. We also provide and underscore the appropriate guidelines to abide by when attempting to control infections with such resistant isolates. This case also demonstrates the importance of definitive treatment with LVAD removal and transplantation as a component of appropriate management of invasive LVAD infections. In addition, we suggest that even infections with MDR organisms may not adversely affect post-transplant outcomes.

Original languageEnglish (US)
JournalTransplant Infectious Disease
Volume14
Issue number5
DOIs
StatePublished - Oct 2012

Fingerprint

Daptomycin
Heart-Assist Devices
Methicillin-Resistant Staphylococcus aureus
Infection
Device Removal
Therapeutics
Infection Control
Transplantation
Guidelines
Transplants
Equipment and Supplies
Population

Keywords

  • Daptomycin non-susceptibility
  • Heart transplant
  • Infection
  • Left ventricular assist device
  • MRSA

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Successful treatment of a left ventricular assist device infection with daptomycin non-susceptible methicillin-resistant Staphylococcus aureus : Case report and review of the literature. / Levy, D. T.; Steed, M. E.; Rybak, M. J.; Guo, Y.; Gialanella, Philip; Hanau, L.; Muggia, V.; Ostrowsky, B.

In: Transplant Infectious Disease, Vol. 14, No. 5, 10.2012.

Research output: Contribution to journalArticle

@article{fa2ba7ccf7684e37a76332ce2e562187,
title = "Successful treatment of a left ventricular assist device infection with daptomycin non-susceptible methicillin-resistant Staphylococcus aureus: Case report and review of the literature",
abstract = "Recipients of left ventricular assist devices (LVADs) are highly susceptible to the development of infections with multidrug- resistant (MDR) organisms. We describe the case of a patient with an LVAD who developed a device-related, daptomycin non-susceptible, methicillin-resistant Staphylococcus aureus infection, highlighting this patient population as highly vulnerable to the development of such antimicrobial resistance. This report includes a thorough review of the literature on the mechanisms of development of daptomycin non-susceptibility and suggests ways to prevent its emergence. We also provide and underscore the appropriate guidelines to abide by when attempting to control infections with such resistant isolates. This case also demonstrates the importance of definitive treatment with LVAD removal and transplantation as a component of appropriate management of invasive LVAD infections. In addition, we suggest that even infections with MDR organisms may not adversely affect post-transplant outcomes.",
keywords = "Daptomycin non-susceptibility, Heart transplant, Infection, Left ventricular assist device, MRSA",
author = "Levy, {D. T.} and Steed, {M. E.} and Rybak, {M. J.} and Y. Guo and Philip Gialanella and L. Hanau and V. Muggia and B. Ostrowsky",
year = "2012",
month = "10",
doi = "10.1111/j.1399-3062.2012.00775.x",
language = "English (US)",
volume = "14",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Successful treatment of a left ventricular assist device infection with daptomycin non-susceptible methicillin-resistant Staphylococcus aureus

T2 - Case report and review of the literature

AU - Levy, D. T.

AU - Steed, M. E.

AU - Rybak, M. J.

AU - Guo, Y.

AU - Gialanella, Philip

AU - Hanau, L.

AU - Muggia, V.

AU - Ostrowsky, B.

PY - 2012/10

Y1 - 2012/10

N2 - Recipients of left ventricular assist devices (LVADs) are highly susceptible to the development of infections with multidrug- resistant (MDR) organisms. We describe the case of a patient with an LVAD who developed a device-related, daptomycin non-susceptible, methicillin-resistant Staphylococcus aureus infection, highlighting this patient population as highly vulnerable to the development of such antimicrobial resistance. This report includes a thorough review of the literature on the mechanisms of development of daptomycin non-susceptibility and suggests ways to prevent its emergence. We also provide and underscore the appropriate guidelines to abide by when attempting to control infections with such resistant isolates. This case also demonstrates the importance of definitive treatment with LVAD removal and transplantation as a component of appropriate management of invasive LVAD infections. In addition, we suggest that even infections with MDR organisms may not adversely affect post-transplant outcomes.

AB - Recipients of left ventricular assist devices (LVADs) are highly susceptible to the development of infections with multidrug- resistant (MDR) organisms. We describe the case of a patient with an LVAD who developed a device-related, daptomycin non-susceptible, methicillin-resistant Staphylococcus aureus infection, highlighting this patient population as highly vulnerable to the development of such antimicrobial resistance. This report includes a thorough review of the literature on the mechanisms of development of daptomycin non-susceptibility and suggests ways to prevent its emergence. We also provide and underscore the appropriate guidelines to abide by when attempting to control infections with such resistant isolates. This case also demonstrates the importance of definitive treatment with LVAD removal and transplantation as a component of appropriate management of invasive LVAD infections. In addition, we suggest that even infections with MDR organisms may not adversely affect post-transplant outcomes.

KW - Daptomycin non-susceptibility

KW - Heart transplant

KW - Infection

KW - Left ventricular assist device

KW - MRSA

UR - http://www.scopus.com/inward/record.url?scp=84867658546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867658546&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3062.2012.00775.x

DO - 10.1111/j.1399-3062.2012.00775.x

M3 - Article

C2 - 22931050

AN - SCOPUS:84867658546

VL - 14

JO - Transplant Infectious Disease

JF - Transplant Infectious Disease

SN - 1398-2273

IS - 5

ER -