Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma

U. Steidl, R. Fenk, I. Bruns, F. Neumann, M. Kondakci, B. Hoyer, T. Gräf, U. P. Rohr, S. Bork, R. Kronenwett, R. Haas, G. Kobbe

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Following induction therapy and 4g/m2 cyclophosphamide, a single dose of 12mg polyethyleneglycol-conjugated G-CSF (pegfilgrastim; n = 12) or daily doses of unconjugated G-CSF (8.5 μg/kg/day) (n = 12) were administered to myeloma patients. Pegfilgrastim was associated with an earlier leukocyte recovery (12 vs 14 days) and peripheral blood CD34 + cell peak (12 vs 15 days). The peripheral blood CD34 + cell peak was lower in the pegfilgrastim group (78 vs 111/μl). Following high-dose melphalan (200mg/m2) and autografting, leukocyte and platelet reconstitution was similar in both groups and stable blood counts were observed 100 days post transplant. In summary, a single dose of pegfilgrastim after chemotherapy is capable of mobilizing a sufficient number of CD34 + cells for successful autografting with early engraftment and sustained hematological reconstitution in patients with myeloma. These data provide the basis for randomized studies evaluating the optimal dose and time of pegfilgrastim as well as long-term outcome in larger cohorts of patients.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalBone Marrow Transplantation
Volume35
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Keywords

  • G-CSF
  • Multiple myeloma
  • Polyethylenglycole
  • Stem cell mobilization
  • Stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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