Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis

K. Shiva Kumar, Jay Lefkowitch, Mark W. Russo, Charles Hesdorffer, Milan Kinkhabwala, Sandip Kapur, Jean C. Emond, Robert S. Brown

Research output: Contribution to journalArticle

37 Scopus citations


We report on a patient with primary AL amyloidosis who presented with progressive liver failure secondary to hepatic infiltration in the absence of significant extrahepatic involvement. Orthotopic liver transplantation was performed successfully. After an uneventful postoperative course, the patient developed evidence of significant recurrent amyloidosis requiring treatment. He then underwent stem cell transplantation 10 and 14 months after liver transplantation. After 28 months of follow-up posttransplantation, the patient continues to do well, with no clinical evidence of recurrent disease. This is the first reported patient with primary amyloidosis to undergo sequential liver and stem cell transplantation leading to resolution of the disease and only the second to undergo successful liver transplantation for this disorder.

Original languageEnglish (US)
Pages (from-to)2026-2031
Number of pages6
Issue number7
Publication statusPublished - Jun 2002
Externally publishedYes


ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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