Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis

K. Shiva Kumar, Jay Lefkowitch, Mark W. Russo, Charles Hesdorffer, Milan Kinkhabwala, Sandip Kapur, Jean C. Emond, Robert S. Brown

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We report on a patient with primary AL amyloidosis who presented with progressive liver failure secondary to hepatic infiltration in the absence of significant extrahepatic involvement. Orthotopic liver transplantation was performed successfully. After an uneventful postoperative course, the patient developed evidence of significant recurrent amyloidosis requiring treatment. He then underwent stem cell transplantation 10 and 14 months after liver transplantation. After 28 months of follow-up posttransplantation, the patient continues to do well, with no clinical evidence of recurrent disease. This is the first reported patient with primary amyloidosis to undergo sequential liver and stem cell transplantation leading to resolution of the disease and only the second to undergo successful liver transplantation for this disorder.

Original languageEnglish (US)
Pages (from-to)2026-2031
Number of pages6
JournalGastroenterology
Volume122
Issue number7
StatePublished - 2002
Externally publishedYes

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Liver Failure
Stem Cell Transplantation
Liver Transplantation
Liver
Amyloidosis
Primary amyloidosis
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kumar, K. S., Lefkowitch, J., Russo, M. W., Hesdorffer, C., Kinkhabwala, M., Kapur, S., ... Brown, R. S. (2002). Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis. Gastroenterology, 122(7), 2026-2031.

Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis. / Kumar, K. Shiva; Lefkowitch, Jay; Russo, Mark W.; Hesdorffer, Charles; Kinkhabwala, Milan; Kapur, Sandip; Emond, Jean C.; Brown, Robert S.

In: Gastroenterology, Vol. 122, No. 7, 2002, p. 2026-2031.

Research output: Contribution to journalArticle

Kumar, KS, Lefkowitch, J, Russo, MW, Hesdorffer, C, Kinkhabwala, M, Kapur, S, Emond, JC & Brown, RS 2002, 'Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis', Gastroenterology, vol. 122, no. 7, pp. 2026-2031.
Kumar, K. Shiva ; Lefkowitch, Jay ; Russo, Mark W. ; Hesdorffer, Charles ; Kinkhabwala, Milan ; Kapur, Sandip ; Emond, Jean C. ; Brown, Robert S. / Successful sequential liver and stem cell transplantation for hepatic failure due to primary AL amyloidosis. In: Gastroenterology. 2002 ; Vol. 122, No. 7. pp. 2026-2031.
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