Successful management of intractable cryptosporidial diarrhea with intravenous octreotide, a somatostatin analogue

L. M. Weiss, M. Wittner, G. Kreinik, O. Burstein, M. Landor, L. Bernstein

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A 38-year-old man with AIDS and intractable large-volume diarrhea due to a cryptosporidial infection was successfully treated with intravenous octreotide, a somatostatin analogue. The volume of diarrhea, 10-12 liters with 8-13 movements per day, was reduced to three to four semi-formed to formed stools per day when the patient was treated with 400 μg intravenous octreotide daily. The patient's intravenous hyperalimentation was discontinued and he returned to oral feeding. He quickly regained his normal weight and has now resumed his normal activites. For those patients who cannot tolerate subcutaneous administration, intravenous octreotide therapy may not only be life-saving but may also markedly increase the quality of life. Roxithromycin, a macrolide antibiotic, was also administered to this patient with cryptosporidiosis but efficacy was not demonstrated.

Original languageEnglish (US)
Pages (from-to)765-767
Number of pages3
JournalAIDS
Volume5
Issue number6
StatePublished - Jul 17 1991

Keywords

  • cryptosporidiosis
  • diarrhea
  • octreotide
  • roxithromycin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Weiss, L. M., Wittner, M., Kreinik, G., Burstein, O., Landor, M., & Bernstein, L. (1991). Successful management of intractable cryptosporidial diarrhea with intravenous octreotide, a somatostatin analogue. AIDS, 5(6), 765-767.