Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus

Ugochi O. Ogu, Ghada Abusin, Rolla Abu-Arja, Janice Staber

Research output: Contribution to journalArticle

Abstract

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.
Original languageEnglish (US)
Article number7654278
Number of pages5
JournalCase Reports in Pediatrics
Volume2018
DOIs
StatePublished - Oct 8 2018

Fingerprint

Sirolimus
Blood Transfusion
Gastrointestinal Tract
Vascular Malformations
Iron-Deficiency Anemias
Rare Diseases
Hemorrhage
Skin
Blue rubber bleb nevus syndrome

ASJC Scopus subject areas

  • Hematology
  • Pediatrics, Perinatology, and Child Health

Cite this

Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus. / Ogu, Ugochi O.; Abusin, Ghada; Abu-Arja, Rolla; Staber, Janice.

In: Case Reports in Pediatrics, Vol. 2018, 7654278, 08.10.2018.

Research output: Contribution to journalArticle

Ogu, Ugochi O. ; Abusin, Ghada ; Abu-Arja, Rolla ; Staber, Janice. / Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus. In: Case Reports in Pediatrics. 2018 ; Vol. 2018.
@article{32dc06225b7a4ff897a0747510d3d85b,
title = "Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus",
abstract = "Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.",
author = "Ogu, {Ugochi O.} and Ghada Abusin and Rolla Abu-Arja and Janice Staber",
year = "2018",
month = "10",
day = "8",
doi = "10.1155/2018/7654278",
language = "English (US)",
volume = "2018",
journal = "Case Reports in Pediatrics",
publisher = "Hindawi Limited",

}

TY - JOUR

T1 - Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus

AU - Ogu, Ugochi O.

AU - Abusin, Ghada

AU - Abu-Arja, Rolla

AU - Staber, Janice

PY - 2018/10/8

Y1 - 2018/10/8

N2 - Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.

AB - Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.

U2 - 10.1155/2018/7654278

DO - 10.1155/2018/7654278

M3 - Article

VL - 2018

JO - Case Reports in Pediatrics

JF - Case Reports in Pediatrics

M1 - 7654278

ER -