Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus

Ugochi O. Ogu; Ghada Abusin; Rolla Abu-Arja; Janice Staber

doi:10.1155/2018/7654278

Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus

Ugochi O. Ogu, Ghada Abusin, Rolla Abu-Arja, Janice Staber

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.

Original language	English (US)
Article number	7654278
Number of pages	5
Journal	Case Reports in Pediatrics
Volume	2018
DOIs	https://doi.org/10.1155/2018/7654278
State	Published - Oct 8 2018

ASJC Scopus subject areas

Hematology
Pediatrics, Perinatology, and Child Health

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title = "Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus",

abstract = "Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.",

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AB - Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.

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DO - 10.1155/2018/7654278

M3 - Article

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JO - Case Reports in Pediatrics

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M1 - 7654278

ER -

Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus

Abstract

ASJC Scopus subject areas

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